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首页> 外文期刊>Chest: The Journal of Circulation, Respiration and Related Systems >Obesity-associated severe asthma represents a distinct clinical phenotype analysis of the british thoracic society diffi cult asthma registry patient cohort according to bmi
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Obesity-associated severe asthma represents a distinct clinical phenotype analysis of the british thoracic society diffi cult asthma registry patient cohort according to bmi

机译：肥胖相关的重度哮喘代表了英国胸学会难治性哮喘登记患者队列的一项独特的临床表型分析

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Background: Obesity has emerged as a risk factor for the development of asthma and it may also influence asthma control and airway infl ammation. However, the role of obesity in severe asthma remains unclear. Thus, our objective was to explore the association between obesity (defi ned by BMI) and severe asthma. Methods: Data from the British Thoracic Society Diffi cult Asthma Registry were used to compare patient demographics, disease characteristics, and health-care utilization among three BMI categories (normal weight: 18.5-24.99; overweight: 25-29.99; obese: - 30) in a well-characterized group of adults with severe asthma. Results: The study population consisted of 666 patients with severe asthma; the group had a median BMI of 29.8 (interquartile range, 22.5-34.0). The obese group exhibited greater asthma medication requirements in terms of maintenance corticosteroid therapy (48.9% vs 40.4% and 34.5% in the overweight and normal-weight groups, respectively), steroid burst therapy, and short-acting b 2 -agonist use per day. Signifi cant differences were seen with gastroesophageal reflux disease (53.9% vs 48.1% and 39.7% in the overweight and normal weight groups, respectively) and proton pump inhibitor use. Bone density scores were higher in the obese group, while pulmonary function testing revealed a reduced FVC and elevated carbon monoxide transfer coeffi - cient. Serum IgE levels decreased with increasing BMI and the obese group was more likely to report eczema, but less likely to have a history of nasal polyps. Conclusions: Patients with severe asthma display particular characteristics according to BMI that support the view that obesity-associated severe asthma may represent a distinct clinical phenotype. CHEST 2013; 143(2):406-414
机译：背景：肥胖已成为哮喘发作的危险因素，它也可能影响哮喘控制和气道炎症。但是，肥胖在重度哮喘中的作用尚不清楚。因此，我们的目标是探讨肥胖（由BMI定义）与严重哮喘之间的关系。方法：使用英国胸科学会困难哮喘登记处的数据来比较三种BMI类别（正常体重：18.5-24.99;超重：25-29.99;肥胖：-30）中的患者人口统计学，疾病特征和医疗保健利用率在特征明确的一组患有严重哮喘的成年人中结果：研究人群包括666例重度哮喘患者。该组的BMI中位数为29.8（四分位间距为22.5-34.0）。肥胖组在维持皮质类固醇激素治疗方面表现出更高的哮喘药物治疗需求（超重和正常体重组分别为48.9％和40.4％和34.5％），类固醇爆裂疗法和每天使用短效b 2-激动剂。胃食管反流疾病和质子泵抑制剂的使用在胃食管反流疾病方面有显着差异（超重和正常体重组分别为53.9％，48.1％和39.7％）。肥胖组的骨密度评分较高，而肺功能测试显示FVC降低和一氧化碳转移系数升高。血清IgE水平随BMI的增加而降低，肥胖组更容易报告湿疹，但不太可能有鼻息肉病史。结论：根据BMI，重度哮喘患者表现出特殊的特征，这支持肥胖相关的重度哮喘可能代表了独特的临床表型的观点。胸部2013; 143（2）：406-414

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