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Culturally Tailored Smoking Cessation for Adult American Indian Smokers: A Clinical Trial

机译:针对成年美洲印第安人吸烟者的量身定制的戒烟措施:一项临床试验

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摘要

This collaborative, community-engaged project developed and tested a Culturally Tailored Treatment (CTT) for American Indian/Alaska Native (Al/ AN) smokers in the Menominee tribal community. One hundred three adult AI/AN smokers were randomized to receive either Standard Treatment (ST; n = 53) or CTT (n = 50) for smoking cessation. Both treatment conditions included 12 weeks of varenicline and four individual counseling sessions but differed in terms of cultural tailoring of the counseling. The primary outcome was 7-day, biochemically confirmed point-prevalence abstinence (PPA) at the 6-month end-of-study visit. Both intention-to-treat (ITT) and responder-only analyses were conducted. There were no statistically significant group differences in 7-day PPA. The overall ITT abstinence rate at 6 months was 20%; the responder-only rate was 42%. The current study represents the first randomized smoking cessation clinical trial testing a culturally tailored smoking cessation intervention designed for a specific AI/AN tribal community that combined Food and Drug Administration (FDA)-approved cessation medication (varenicline) and innovative cultural intervention components.
机译:这个社区参与的合作项目为Menominee部落社区的美国印第安人/阿拉斯加原住民(Al / AN)吸烟者开发并测试了文化量身定制的治疗(CTT)。一百零三名成人AI / AN吸烟者被随机分组​​接受标准戒烟(ST; n = 53)或CTT(n = 50)。两种治疗条件均包括12周的伐尼克兰治疗和4次单独的咨询会议,但在咨询的文化调整方面有所不同。主要结局是在为期6个月的研究结束时进行7天的生化点抑制节制(PPA)。进行了意向性治疗(ITT)和仅响应者的分析。在7天的PPA中,没有统计学上显着的组差异。 6个月时ITT的总体戒断率为20%;仅有回应者的比率为42%。当前的研究代表了第一个随机戒烟临床试验,该试验测试了针对特定AI / AN部落社区的文化定制的戒烟干预措施,该干预措施结合了食品和药物管理局(FDA)批准的戒烟药物(varenicline)和创新的文化干预措施。

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