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首页> 外文期刊>The European Journal of Neuroscience >Activation of reward circuitry in human opiate addicts.
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Activation of reward circuitry in human opiate addicts.

机译:激活人类阿片成瘾者的奖励电路。

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摘要

The neurobiological mechanisms of opiate addictive behaviour in humans are unknown. A proposed model of addiction implicates ascending brainstem neuromodulatory systems, particularly dopamine. Using functional neuroimaging, we assessed the neural response to heroin and heroin-related cues in established opiate addicts. We show that the effect of both heroin and heroin-related visual cues are maximally expressed in the sites of origin of ascending midbrain neuromodulatory systems. These context-specific midbrain activations predict responses to salient visual cues in cortical and subcortical regions implicated in reward-related behaviour. These findings implicate common neurobiological processes underlying drug and drug-cue-related effects.
机译:人类鸦片成瘾行为的神经生物学机制尚不清楚。拟议的成瘾模型牵涉上升的脑干神经调节系统,特别是多巴胺。使用功能性神经影像学,我们评估了已建立的鸦片成瘾者对海洛因和海洛因相关线索的神经反应。我们表明,海洛因和与海洛因有关的视觉提示的效果在中脑神经调节系统的起源部位得到了最大程度的表达。这些特定于上下文的中脑激活可预测对涉及奖励相关行为的皮层和皮层下区域明显视觉提示的反应。这些发现暗示了与药物和药物提示相关作用有关的常见神经生物学过程。

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