...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The European Journal of Neuroscience >Evidence for topographically organized endogenous 5-HT-1A receptor-dependent feedback inhibition of the ascending serotonin system.
【24h】

Evidence for topographically organized endogenous 5-HT-1A receptor-dependent feedback inhibition of the ascending serotonin system.

机译：地形组织内源性5-HT-1A受体依赖性反馈抑制5-羟色胺系统的证据。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Raphe and extra-raphe 5-HT-1A receptors contribute to feedback inhibition of serotonin (5-HT) neurons; however, the endogenous function of 5-HT-1A receptor-dependent feedback inhibition remains poorly understood. Here, the possibility that 5-HT-1A-mediated feedback inhibition of the raphe nuclei is topographically organized was examined. This was done by testing the effect of systemic blockade of 5-HT-1A receptors on Fos expression in 5-HT neurons in the dorsal raphe (DR) and median raphe (MR). The premise was that appearance of Fos after 5-HT-1A receptor blockade would implicate endogenous inhibition via 5-HT-1A-dependent processes. 5-HT-1A receptor antagonist administration (WAY-100635) in rats returned to their home cage significantly increased the number of Fos-containing 5-HT cells in the lateral wings and the ventral caudal part of the DR as compared to vehicle-injected controls, suggesting that tonic activity of brain 5-HT-1A receptors impacts on these regions. In rats receiving vehicle injections, swim, a behavior known to influence 5-HT neurotransmission, increased the number of Fos-containing 5-HT cells only in the caudal third of DR. Administration of WAY-100635 preceding a swim did not change the amount of Fos in the caudal DR, but increased the number of Fos-containing 5-HT cells in the rostral DR, lateral wings of the DR, and MR. These results confirm, using an imaging approach, that 5-HT-1A receptor-dependent feedback inhibition depends on behavioral state (return to home cage vs. swim). Moreover, they reveal that the effect of 5-HT-1A receptor blockade in each case is subregionally organized.
机译：Raphe和超强奸的5-HT-1A受体有助于5-羟色胺（5-HT）神经元的反馈抑制。然而，5-HT-1A受体依赖性反馈抑制的内源性功能仍然知之甚少。在此，研究了5-HT-1A介导的缝核的反馈抑制在地形上组织的可能性。通过测试5-HT-1A受体的全身性阻断对背on（DR）和正中ra（MR）中5-HT神经元中Fos表达的影响来完成。前提是5-HT-1A受体阻断后Fos的出现将暗示通过5-HT-1A依赖性过程的内源性抑制。与媒介物注射相比，在大鼠返回其家禽笼中施用5-HT-1A受体拮抗剂（WAY-100635）显着增加了DR侧翼和腹侧腹部分含Fos的5-HT细胞的数量对照，表明大脑5-HT-1A受体的强直活动影响这些区域。在接受媒介物注射的大鼠中，游泳是一种已知会影响5-HT神经传递的行为，仅在DR的尾部三分之一处会增加含Fos的5-HT细胞的数量。游泳前给予WAY-100635不会改变尾DR中Fos的量，但增加了鼻端DR，DR的侧翼和MR中含Fos的5-HT细胞的数量。这些结果使用成像方法证实了5-HT-1A受体依赖性反馈抑制取决于行为状态（回到笼中还是游泳）。此外，他们揭示了在每种情况下5-HT-1A受体阻滞的作用都是分区域组织的。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号