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首页> 外文期刊>The European Journal of Neuroscience >A centrifugal pathway to the mouse accessory olfactory bulb from the medial amygdala conveys gender-specific volatile pheromonal signals.
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A centrifugal pathway to the mouse accessory olfactory bulb from the medial amygdala conveys gender-specific volatile pheromonal signals.

机译：从杏仁核内侧到小鼠副嗅球的离心路径传达了特定于性别的挥发性信息素信号。

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We previously found that female mice exhibited Fos responses in the accessory olfactory bulb (AOB) after exposure to volatile opposite-sex, but not same-sex, urinary odours. This effect was eliminated by lesioning the main olfactory epithelium, raising the possibility that the AOB receives information about gender via centrifugal inputs originating in the main olfactory system instead of from the vomeronasal organ. We asked which main olfactory forebrain targets send axonal projections to the AOB, and whether these input neurons express Fos in response to opposite-sex urinary volatiles. Female mice received bilateral injections of the retrograde tracer cholera toxin B (CTB), into the AOB, and were exposed to either same- or opposite-sex volatile urinary odours 1 week later. We found CTB-labeled cell bodies in several forebrain sites including the bed nucleus of the accessory olfactory tract, the rostral portion of the medial amygdala (MeA) and the posteromedial cortical nucleus of the amygdala. A significant increase in the percentage of CTB/Fos co-labeled cells was seen only in the MeA of female subjects exposed to male but not to female urinary volatiles. In Experiment 2, CTB-injected females were later exposed to volatile odours from male mouse urine, food, or cat urine. Again, a significant increase in the percentage of CTB/Fos co-labeled cells was seen in the MeA of females exposed to male mouse urinary volatiles but not to food or predator odours. Main olfactory-MeA-AOB signaling may motivate approach behaviour to opposite-sex pheromonal signals that ensure successful reproduction.
机译：我们先前发现，雌性小鼠在暴露于挥发性的异性而非同性的尿臭味后，在副嗅球（AOB）中表现出Fos反应。通过损害主要嗅觉上皮细胞可以消除这种影响，从而提高了AOB通过起源于主要嗅觉系统而不是来自犁鼻鼻器官的离心输入来接收有关性别的信息的可能性。我们询问了哪个主要嗅觉前脑目标将轴突投影发送到AOB，以及这些输入神经元是否响应异性泌尿挥发物而表达Fos。雌性小鼠接受了向AOB的双侧逆行示踪示踪霍乱毒素B（CTB）注射，并于1周后暴露于同性或异性挥发性尿臭味中。我们在几个前脑部位发现了CTB标记的细胞体，包括副嗅觉的床核，杏仁核的内侧部分（MeA）和杏仁核的后内侧皮质核。仅在暴露于男性但未暴露于女性尿挥发物的女性受试者的MeA中才能看到CTB / Fos共标记细胞百分比的显着增加。在实验2中，注射CTB的雌性随后暴露于雄性小鼠尿液，食物或猫尿中的挥发性气味。再次，在暴露于雄性小鼠尿液挥发分而不是食物或捕食者气味的雌性动物的MeA中，发现CTB / Fos共标记细胞的百分比显着增加。主要的嗅觉-MeA-AOB信号可能促使接近性行为向确保成功繁殖的异性信息素信号。

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