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首页> 外文期刊>The European Journal of Neuroscience >Influence of photoperiod duration and light-dark transitions on entrainment of Per1 and Per2 gene and protein expression in subdivisions of the mouse suprachiasmatic nucleus.
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Influence of photoperiod duration and light-dark transitions on entrainment of Per1 and Per2 gene and protein expression in subdivisions of the mouse suprachiasmatic nucleus.

机译：光周期持续时间和明暗转换对小鼠视交叉上核细分区Per1和Per2基因的夹带和蛋白质表达的影响。

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摘要

The circadian clock located within the suprachiasmatic nuclei (SCN) of the hypothalamus responds to changes in the duration of day length, i.e. photoperiod. Recently, changes in phase relationships among the SCN cell subpopulations, especially between the rostral and caudal region, were implicated in the SCN photoperiodic modulation. To date, the effect of abrupt, rectangular, light-to-dark transitions have been studied while in nature organisms experience gradual dawn and twilight transitions. The aim of this study was to compare the effect of a long (18 h of light) and a short (6 h of light) photoperiod with twilight relative to that with rectangular light-to-dark transition on the daily profiles of Per1 and Per2 mRNA (in situ hybridization) and PER1 and PER2 protein (immunohistochemistry) levels within the rostral, middle and caudal regions of the mouse SCN. Under the short but not under the long photoperiod, Per1, Per2 and PER1, PER2 profiles were significantly phase-advanced under the twilight relative to rectangular light-to-dark transition in all SCN regions examined. Under the photoperiods with rectangular light-to-dark transition, Per1 and Per2 mRNA profiles in the caudal SCN were phase-advanced as compared with those in the rostral SCN. The phase differences between the SCN regions were reduced under the long, or completely abolished under the short, photoperiods with twilight. The data indicate that the twilight photoperiod provides stronger synchronization among the individual SCN cell subpopulations than the rectangular one, and the effect is more pronounced under the short than under the long photoperiod.
机译：位于下丘脑上眼睑上核（SCN）内的昼夜节律钟对白天的持续时间即光周期的变化作出响应。最近，SCN光周期调制涉及SCN细胞亚群之间，特别是在鼻和尾区之间的相位关系的变化。迄今为止，已经研究了突然的，矩形的，从明暗过渡的影响，而在自然界中，生物体经历了逐渐的黎明和暮光过渡。这项研究的目的是比较长期（18 h的光）和短暂（6 h的光）的光周期与微明相对于矩形从明暗过渡的光周期对Per1和Per2每日分布的影响小鼠SCN的喙，中部和尾部区域内的mRNA（原位杂交）以及PER1和PER2蛋白（免疫组织化学）水平。在短而长的光周期下，Per1，Per2和PER1在相对于所有所检查的SCN区域中，从矩形到明暗过渡，在暮光下，Per1，Per2和PER2的轮廓显着相移。在具有从明到暗矩形过渡的光周期下，与尾状SCN相比，尾状SCN中的Per1和Per2 mRNA谱相提前。 SCN区域之间的相位差在较长的光周期下随着微弱的时间减少，或在短的光周期下完全消失。数据表明，与矩形的相比，暮光光周期在各个SCN细胞亚群之间提供了更强的同步性，并且在短时间下比在长光周期下更明显。

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