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首页> 外文期刊>The European Journal of Neuroscience >Gamma activity and reactivity in human thalamic local field potentials.
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Gamma activity and reactivity in human thalamic local field potentials.

机译：伽马活性和人类丘脑局部场电势中的反应性。

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Depth recordings in patients with Parkinson's disease on dopaminergic therapy have revealed a tendency for oscillatory activity in the basal ganglia that is sharply tuned to frequencies of approximately 70 Hz and increases with voluntary movement. It is unclear whether this activity is essentially physiological and whether it might be involved in arousal processes. Here we demonstrate an oscillatory activity with similar spectral characteristics and motor reactivity in the human thalamus. Depth signals were recorded in 29 patients in whom the ventral intermediate or centromedian nucleus were surgically targeted for deep brain stimulation. Thirteen patients with four different pathologies showed sharply tuned activity centred at approximately 70 Hz in spectra of thalamic local field potential (LFP) recordings. This activity was modulated by movement and, critically, varied over the sleep-wake cycle, being suppressed during slow wave sleep and re-emergent during rapid eye movement sleep, which physiologically bears strong similarities with the waking state. It was enhanced by startle-eliciting stimuli, also consistent with modulation by arousal state. The link between this pattern of thalamic activity and that of similar frequency in the basal ganglia was strengthened by the finding that fast thalamic oscillations were lost in untreated parkinsonian patients, paralleling the behaviour of this activity in the basal ganglia. Furthermore, there was sharply tuned coherence between thalamic and pallidal LFP activity at approximately 70 Hz in eight out of the 11 patients in whom globus pallidus and thalamus were simultaneously implanted. Subcortical oscillatory activity at approximately 70 Hz may be involved in movement and arousal.
机译：多巴胺能疗法治疗帕金森氏病患者的深度记录显示，基底神经节有振荡活动的趋势，该趋势已急剧调整到约70 Hz的频率，并随自发运动而增加。目前尚不清楚这种活动是否本质上是生理的，是否可能与唤醒过程有关。在这里，我们证明了人类丘脑中具有类似的光谱特征和运动反应性的振荡活动。在29例患者中记录了深度信号，其中以腹侧中间或着丝粒体核为手术目标，以进行深部脑刺激。在丘脑局部场电势（LFP）记录的频谱中，有四种不同病理的13名患者显示出以大约70 Hz为中心的剧烈调整的活动。该活动通过运动来调节，并且在整个睡眠-觉醒周期中变化，在慢波睡眠时受到抑制，而在快速眼动睡眠时又重新出现，这在生理上与清醒状态具有相似性。它通过惊吓引起的刺激而增强，也与唤醒状态的调节相一致。发现未经治疗的帕金森氏病患者快速丘脑振荡消失，与这种活动在基底神经节中的行为平行，这一发现加强了丘脑活动模式与基底神经节中类似频率的联系。此外，在同时植入苍白球和丘脑的11例患者中，有8例的丘脑和苍白细胞LFP活性在大约70 Hz时具有明显的一致性。大约70 Hz的皮层下振荡活动可能与运动和唤醒有关。

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