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首页> 外文期刊>The European Journal of Neuroscience >Brief exposure of juvenile rats to noise impairs the development of the response properties of inferior colliculus neurons.
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Brief exposure of juvenile rats to noise impairs the development of the response properties of inferior colliculus neurons.

机译：幼鼠短暂接触噪声会损害下丘神经元的响应特性。

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Temporary impairment of the auditory periphery during the sensitive period of postnatal development of rats may result in a deterioration of neuronal responsiveness in the central auditory nuclei of adult animals. In this study, juvenile rats (postnatal day 14) were exposed for 8 min to intense broad-band noise; at the age of 3-6 months, the excitatory and inhibitory response areas of neurons in the central nucleus of the inferior colliculus were recorded under ketamine-xylazine anaesthesia in these animals and compared with those of age-matched controls. The response thresholds were similar in the exposed and control animals. The frequency selectivity of low-frequency neurons was comparable in both groups; however, high-frequency neurons had significantly wider excitatory response areas in the exposed rats, indicating disrupted development of high-frequency hearing. Forty-one per cent and 25% of neurons in exposed animals and in controls, respectively, lacked a distinct inhibitory area; these neurons had similar frequency selectivity in the exposed and control rats. As the presence of an inhibitory sideband was associated with sharper frequency tuning in both groups, it appears that lateral inhibition substantially influences neuronal frequency selectivity. If present, the inhibitory areas had comparable bandwidths in both groups; however, they were shifted to the side in the exposed animals, allowing the expansion of the excitatory areas. The results indicate that a brief exposure of juvenile rats to noise leads to a significant worsening of the frequency selectivity of inferior colliculus neurons in adult animals; the poorer frequency selectivity may be due to missing or displaced inhibitory sidebands.
机译：在大鼠出生后发育的敏感时期，听觉周围的暂时性损伤可能导致成年动物中枢听觉核的神经元反应能力下降。在这项研究中，未成年大鼠（出生后第14天）暴露于强烈的宽带噪声下8分钟。在3-6个月大的时候，在氯胺酮-甲苯噻嗪麻醉下记录了这些动物下丘脑中央核神经元的兴奋性和抑制性反应区域，并与年龄相匹配的对照组进行了比较。暴露和对照动物的反应阈值相似。两组中低频神经元的频率选择性相当。然而，在暴露的大鼠中，高频神经元的兴奋反应区域明显更宽，表明高频听力的发育受到干扰。在暴露的动物和对照组中，分别有41％和25％的神经元缺乏明显的抑制区域。这些神经元在暴露和对照大鼠中具有相似的频率选择性。由于两组中抑制性边带的存在都与更陡峭的频率调谐相关，因此似乎横向抑制会显着影响神经元频率选择性。如果存在，则两组抑制区的带宽相当;但是，它们在暴露的动物中转移到一侧，从而扩大了兴奋性区域。结果表明，成年动物短暂暴露于噪声会导致成年动物下丘神经元的频率选择性显着降低。频率选择性较差的原因可能是抑制边带缺失或移位。

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