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首页> 外文期刊>The European Journal of Neuroscience >Fast oscillations in cortical-striatal networks switch frequency following rewarding events and stimulant drugs.
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Fast oscillations in cortical-striatal networks switch frequency following rewarding events and stimulant drugs.

机译：皮质-纹状体网络的快速振荡在奖励事件和刺激性药物之后改变频率。

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Oscillations may organize communication between components of large-scale brain networks. Although gamma-band oscillations have been repeatedly observed in cortical-basal ganglia circuits, their functional roles are not yet clear. Here I show that, in behaving rats, distinct frequencies of ventral striatal local field potential oscillations show coherence with different cortical inputs. The approximately 50 Hz gamma oscillations that normally predominate in awake ventral striatum are coherent with piriform cortex, whereas approximately 80-100 Hz high-gamma oscillations are coherent with frontal cortex. Within striatum, entrainment to gamma rhythms is selective to fast-spiking interneurons, with distinct fast-spiking interneuron populations entrained to different gamma frequencies. Administration of the psychomotor stimulant amphetamine or the dopamine agonist apomorphine causes a prolonged decrease in approximately 50 Hz power and increase in approximately 80-100 Hz power. The same frequency switch is observed for shorter epochs spontaneously in awake, undrugged animals and is consistently provoked for < 1 s following reward receipt. Individual striatal neurons can participate in these brief high-gamma bursts with, or without, substantial changes in firing rate. Switching between discrete oscillatory states may allow different modes of information processing during decision-making and reinforcement-based learning, and may also be an important systems-level process by which stimulant drugs affect cognition and behavior.
机译：振荡可能会组织大型大脑网络的各个组件之间的通信。尽管在皮层-基底神经节回路中反复观察到了伽马带振荡，但它们的功能作用尚不清楚。在这里，我表明，在表现良好的大鼠中，腹侧纹状体局部场电位振荡的不同频率显示出与不同皮质输入有关的相干性。通常在清醒的腹侧纹状体中占主导的大约50 Hz的伽马振荡与梨状皮层相干，而大约80-100 Hz的高伽马振荡与额叶皮层相干。在纹状体中，对伽玛节律的夹带对快速加标的中间神经元具有选择性，而截然不同的快速加标的中间神经元群体则加有不同的伽马频率。施用精神运动兴奋剂苯丙胺或多巴胺激动剂阿扑吗啡会导致约50 Hz功率长时间下降，而约80-100 Hz功率上升。在清醒，不吃药的动物中，自发地观察到较短的时期会发生相同的频率切换，并且在收到奖励后持续激发<1 s。个体纹状体神经元可参与这些短暂的高伽玛爆发，无论是否激发频率都有实质性变化。在离散的振动状态之间进行切换可能会在决策和基于强化的学习过程中允许采用不同的信息处理模式，并且可能也是刺激药物影响认知和行为的重要的系统级过程。

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