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首页> 外文期刊>The European Journal of Neuroscience >New electrophysiological mapping combined with MRI in parkinsonian's subthalamic region.
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New electrophysiological mapping combined with MRI in parkinsonian's subthalamic region.

机译：帕金森氏丘脑下丘脑区结合MRI的新电生理标测。

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The subthalamic nucleus (STN) is the main target for deep brain stimulation in Parkinson's disease. We analysed the relationships between magnetic resonance imaging (MRI) anatomy and spontaneous neuronal activity to confirm the potential of microelectrode recordings to assist in determining the optimal surgical target. Ten bilateral surgeries were performed after 1.5-T (T2-weighted) anatomical MRI identification of the STN, zona incerta (ZI), Forel's field H2 (H2) and substantia nigra (SN). Spontaneous neuronal activity was recorded simultaneously along the distal 10 mm on a central track (optimally covering the STN) and a 2-mm anterior track. We calculated off-line mean firing rate and burst frequency on 248 neurons clustered according to anatomical structure. Subjective visual analysis of signal was also realized on-line, during surgery, to classify patterns of activity. Mean firing rate and burst frequency increased from H2-ZI to SN. The mean firing rate was higher in SN only using paired comparison(SN vs. its neighbours). The burst frequency was lower in H2 than in SN; using comparison with neighbours, it was lower in H2 and ZI. An irregular high activity (type 2C) was more often detected in STN and SN than in H2 and ZI. Anatomical boundaries and unitary recordings appear to be linked, supporting the ability of MRI to provide a detailed anatomy. Electrophysiological mapping combined with MRI is a useful tool for precise targeting in the subthalamic region.
机译：丘脑下核（STN）是帕金森氏病深部脑刺激的主要目标。我们分析了磁共振成像（MRI）解剖结构与自发神经元活动之间的关系，以确认微电极记录的潜力，以帮助确定最佳手术目标。在对STN，不透明带（ZI），Forel视野H2（H2）和黑质（SN）进行1.5-T（T2加权）解剖MRI识别后，进行了十次双边手术。在中央轨道（最佳覆盖STN）和2毫米前轨道上沿远端10 mm同时记录自发神经元活动。我们根据解剖结构计算了248个神经元的离线平均放电速率和猝发频率。在手术过程中，还可以在线进行信号的主观视觉分析，以对活动模式进行分类。从H2-ZI到SN，平均发射速率和突发频率增加。仅使用配对比较（SN与邻居比较），SN的平均发射率更高。 H2中的突发频率低于SN中的突发频率;与邻居比较，H2和ZI较低。在STN和SN中比在H2和ZI中更经常检测到不规则的高活性（2C型）。解剖边界和单一记录似乎联系在一起，支持MRI提供详细解剖结构的能力。电生理学成像与MRI相结合是在丘脑下区域精确定位的有用工具。

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