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首页> 外文期刊>The European Journal of Neuroscience >Main olfactory system mediates social buffering of conditioned fear responses in male rats.
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Main olfactory system mediates social buffering of conditioned fear responses in male rats.

机译：主要嗅觉系统介导了雄性大鼠对条件恐惧反应的社会缓冲。

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We previously reported that the presence of a conspecific animal blocked freezing of a male rat in response to an auditory conditioned stimulus that had been paired with foot shocks, as well as associated Fos expression in the paraventricular nucleus. Here we investigated how this 'social buffering' is mediated by examining the contributions of both physical contact and the main olfactory system. Fear-conditioned rats exposed to the conditioned stimulus alone responded by freezing and increased Fos expression in the paraventricular nucleus. However, the presence of another rat, but not a guinea pig, dramatically mitigated these responses, even if the dyad was separated by a wire mesh or a pair of wire meshes 5 cm apart. In contrast, social buffering was absent when a transparent acrylic board was inserted between the double wire mesh. Lesioning of the main olfactory epithelium by injection of ZnSO(4) intranasally also abolished social buffering. Thus, we conclude that the main olfactory system is essential for the social buffering but does not require physical contact between the dyad.
机译：我们以前曾报道说，存在一种具特异性的动物会阻止雄性大鼠的冻结，这是由于对与足部电击以及在脑室旁核中相关的Fos表达配对的听觉条件刺激做出了反应。在这里，我们通过研究身体接触和主要嗅觉系统的作用，研究了这种“社会缓冲”是如何介导的。暴露于条件刺激下的恐惧条件大鼠通过冻结反应并增加脑室旁核中的Fos表达。但是，即使通过一个网孔或一对相距5 cm的网孔分开了二元组，另一只老鼠（而不是豚鼠）的存在也大大减轻了这些反应。相反，当在双丝网之间插入透明的丙烯酸板时，没有社会缓冲。鼻内注射ZnSO（4）对主要嗅觉上皮的损伤也消除了社会缓冲作用。因此，我们得出结论，主要的嗅觉系统对于社会缓冲是必不可少的，但不需要两性之间的身体接触。

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