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首页> 外文期刊>The European Journal of Neuroscience >Thalamo-cortical processing of near-threshold somatosensory stimuli in humans.
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Thalamo-cortical processing of near-threshold somatosensory stimuli in humans.

机译：丘脑皮层处理人体的近阈体感刺激。

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摘要

Somatosensory stimuli elicit complex cortical responses that are discernible as somatosensory evoked potentials (SEPs) in scalp electroencephalographic recordings. Whereas earlier SEP components, occurring up to 100 ms after stimulus delivery, have been labeled 'preconscious', later responses have been associated with stimulus awareness. To date, how far these processes are primarily cortical or comprise additional subcortical operations remains open. Therefore, we recorded thalamic and scalp SEPs evoked by perceived as well as unperceived median nerve stimulation in neurosurgical patients with electrodes implanted into the ventral intermediate nucleus of the thalamus for deep brain stimulation. At stimulation intensities below perceptual threshold, only thalamic SEP components appeared consistently during the first 75 ms after stimulus delivery. Stimulation that was perceived by the patients elicited cortical as well as thalamic SEPs that lasted longer than 75 ms. These results indicate that the thalamus remains active after the primary propagation of a sensory signal to the cortex, and suggest that the transition from elementary to higher-order somatosensory processing is based on thalamo-cortical interactions.
机译：体感刺激引起复杂的皮层反应，在头皮脑电图记录中可将其识别为体感诱发电位（SEP）。尽管较早的SEP组件（在刺激传递后最多100毫秒内发生）已被标记为“前意识”，但后来的反应却与刺激意识相关。迄今为止，这些过程主要是皮层的或包含其他皮层下的手术还有多远。因此，我们在神经外科患者中记录了丘脑和头皮的SEP，这些丘脑和丘脑的SEP均由知觉和不知觉的中枢神经刺激引起，电极植入了丘脑腹侧中核，用于深部脑刺激。在低于知觉阈值的刺激强度下，仅丘脑SEP成分在刺激传递后的最初75毫秒内持续出现。患者感知到的刺激会引起皮层和丘脑的SEP持续时间超过75毫秒。这些结果表明，丘脑在感觉信号初次传播至皮层后仍保持活动状态，并表明从初级到高层的体感处理的过渡是基于丘脑-皮质相互作用。

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