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首页> 外文期刊>The European Journal of Neuroscience >Impulsive choice in hippocampal but not orbitofrontal cortex-lesioned rats on a nonspatial decision-making maze task.
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Impulsive choice in hippocampal but not orbitofrontal cortex-lesioned rats on a nonspatial decision-making maze task.

机译：在非空间决策迷宫任务中，海马但眶额叶皮质病变大鼠的冲动选择。

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Orbitofrontal cortical (OFC) and hippocampal (HPC) lesions in primates and rodents have been associated with impulsive behaviour. We showed previously that OFC- or HPC-lesioned rats chose the immediate low-reward (LR) option in preference to the delayed high-reward (HR) option, where LR and HR were associated with different spatial responses in a uniform grey T-maze. We now report that on a novel nonspatial T-maze task in which the HR and LR options are associated with patterned goal arms (black-and-white stripes vs. gray), OFC-lesioned rats did not show impulsive behaviour, choosing the delayed HR option, and were indistinguishable from controls. In contrast, HPC-lesioned rats exhibited impulsive choice in the nonspatial decision-making task, although they chose the HR option on the majority of trials when there was a 10-s delay associated with both goal arms. The previously reported impairment in OFC-lesioned rats on the spatial version of the intertemporal choice task is unlikely to reflect a general problem with spatial learning, because OFC lesions were without effect on acquisition of the standard reference memory water-maze task and spatial working memory performance (nonmatching-to-place) on the T-maze. The differential effect of OFC lesions on the two versions of the intertemporal choice task may be explained instead in terms of the putative role of OFC in using associative information to represent expected outcomes and generate predictions. The impulsivity in HPC-lesioned rats may reflect impaired temporal information processing, and emphasizes a role for the hippocampus beyond the spatial domain.
机译：灵长类和啮齿类动物的眶额皮质（OFC）和海马（HPC）病变与冲动行为有关。先前我们显示，OFC或HPC损伤的大鼠优先选择立即低回报（LR）选项，而不是延迟高回报（HR）选项，其中LR和HR在统一的灰色T-迷宫。我们现在报告，在一种新颖的非空间T型迷宫任务中，HR和LR选项与图案化的目标臂（黑白条纹与灰色）相关联，OFC损伤的大鼠没有表现出冲动行为，选择了延迟人力资源选项，与控件没有区别。相比之下，HPC损伤的大鼠在非空间决策任务中表现出冲动选择，尽管在大多数试验中，当两个目标臂都有10 s的延迟时，他们选择了HR选项。先前报道的OFC损伤大鼠的时空选择任务在空间版本上的损伤不太可能反映空间学习的一般问题，因为OFC损伤对标准参考记忆水迷宫任务和空间工作记忆的获取没有影响在T迷宫上的表现（不匹配）。相反，可以根据OFC在使用关联信息表示预期结果并生成预测中的假定作用来解释OFC病变对两个版本的跨期选择任务的不同影响。 HPC损伤大鼠的冲动可能反映了时间信息处理受损，并强调了海马在空间域以外的作用。

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