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首页> 外文期刊>The European Journal of Neuroscience >The SCN-independent clocks, methamphetamine and food restriction.
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The SCN-independent clocks, methamphetamine and food restriction.

机译：独立于SCN的时钟，甲基苯丙胺和食物限制。

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摘要

The circadian system in mammals consists of the central clock in the hypothalamic suprachiasmatic nucleus (SCN) and the peripheral clocks in a variety of tissues and organs. The SCN clock entrains to a light-dark cycle and resets the peripheral clocks. In addition, there are at least two other clocks in the circadian domain which are independent of the SCN and which entrain to nonphotic time cues: methamphetamine (MAP)-induced and restricted daily feeding (RF)-induced clocks. Neither the site nor the mechanism of SCN-independent clocks is known. Canonical clock genes for circadian oscillation are not required for the expression of either SCN-independent rhythm. The central catecholaminergic system is probably involved in the expression of the SCN-independent rhythms, especially of the MAP-induced rhythm. MAP-induced activity rhythms in rats and the sleep-wake cycles in humans share unique phenomena such as spontaneous internal desynchronization, circabidian rhythm and nonphotic entrainment, suggesting overlapping oscillatory mechanisms. The SCN-independent clock is an adaptation that regulates behavior in response to nonphotic time cues, and seems to be closely related to the arousal mechanism.
机译：哺乳动物的昼夜节律系统由下丘脑视交叉上核（SCN）的中央时钟和各种组织和器官的外周时钟组成。 SCN时钟带有一个明暗周期，并复位外设时钟。此外，在昼夜节律域中至少有两个其他时钟独立于SCN并带有非光时性信号：甲基苯丙胺（MAP）引起的和限制性每日进食（RF）引起的时钟。站点和SCN无关时钟的机制都未知。昼夜节律振荡的规范时钟基因对于任一SCN独立节律的表达都是不需要的。中央儿茶酚胺能系统可能参与了SCN独立节律的表达，尤其是MAP诱导的节律的表达。 MAP诱导的大鼠活动节律和人类的睡眠-觉醒周期共有独特的现象，例如自发内部失步，昼夜节律和非光合夹带，提示了重叠的振荡机制。独立于SCN的时钟是一种适应行为，可调节响应非光性时间线索的行为，并且似乎与唤醒机制密切相关。

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