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首页> 外文期刊>The European Journal of Neuroscience >Bar pressing for food: differential consequences of lesions to the anterior versus posterior pedunculopontine.
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Bar pressing for food: differential consequences of lesions to the anterior versus posterior pedunculopontine.

机译：压榨食物：病变对前足足和后足足的不同影响。

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The pedunculopontine tegmental nucleus (PPTg) is in a key position to participate in operant reinforcement via its connections with the corticostriatal architecture and the medial reticular formation. Indeed, previous work has demonstrated that rats bearing lesions of the whole PPTg are impaired when learning to make two bar presses for amphetamine reinforcement. Anterior and posterior portions of the PPTg make different anatomical connections, including preferential projections by the anterior PPTg to substantia nigra pars compacta dopamine neurons and by the posterior PPTg to ventral tegmental area dopamine neurons. We wanted to assess the effects of anterior and posterior PPTg ibotenate lesions on rats learning simple and more complex schedules of natural reinforcement. We trained rats with lesions to the anterior PPTg (n = 11) and the posterior PPTg (n = 5) [and appropriate controls (n = 15)] to bar press for food on a variety of fixed-ratio and variable-ratio reinforcement schedules and then during extinction. We found that posterior PPTg-lesioned rats bar pressed at lower rates, were slower to learn to bar press, and often had deficits characteristic of impaired learning and/or motivation. In contrast, anterior PPTg-lesioned rats learned to bar press for reinforcement at normal rates. However, they made errors of perseveration and anticipation throughout many schedules, and pressed at a higher rate than controls during extinction, deficits best characterized as reflecting disorganized response control. Together, these data suggest that the anterior PPTg and posterior PPTg (and their related circuits) contribute differently to reinforcement learning, incentive motivation, and response control, processes that are considered to malfunction in drug addiction.
机译：足桥骨被盖核（PPTg）处于关键位置，可通过其与皮质口角结构和网状结构内侧的连接来参与手术加固。确实，先前的研究表明，在学习制作两个压杆以增强苯丙胺时，患有整个PPTg损伤的大鼠会受到损害。 PPTg的前部和后部形成不同的解剖学联系，包括前PPTg对黑质致密多巴胺神经元的优先投射和后PPTg对腹侧被盖区域多巴胺神经元的优先投射。我们想要评估学习简单和更复杂的自然强化计划的大鼠前，后PPTg ibotenate病变对大鼠的影响。我们训练了具有前PPTg（n = 11）和后PPTg（n = 5）[和适当的对照（n = 15）]病变的大鼠，以压榨各种固定比例和可变比例钢筋上的食物时间表，然后灭绝。我们发现后PPTg损伤的大鼠以较低的速度受压，学习受压的速度较慢，并且经常具有学习和/或动机受损的缺陷特征。相比之下，前PPTg损伤的大鼠学会了以正常速度压迫加压以进行增强。但是，他们在许多时间表中都犯了坚持和预期错误，并且在灭绝过程中以高于对照组的速度受到压迫，其缺陷最能反映出反应控制混乱。总之，这些数据表明，前PPTg和后PPTg（及其相关回路）对强化学习，激励动机和反应控制（被认为是吸毒成瘾的过程）的贡献不同。

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