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首页> 外文期刊>The European Journal of Neuroscience >Functional importance of blood flow dynamics and partial oxygen pressure in the anterior pituitary.
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Functional importance of blood flow dynamics and partial oxygen pressure in the anterior pituitary.

机译:垂体前叶血流动力学和部分氧压的功能重要性。

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摘要

The pulsatile release of hormone is obligatory for the control of a range of important body homeostatic functions. To generate these pulses, endocrine organs have developed finely regulated mechanisms to modulate blood flow both to meet the metabolic demand associated with intense endocrine cell activity and to ensure the temporally precise uptake of secreted hormone into the bloodstream. With a particular focus on the pituitary gland as a model system, we review here the importance of the interplay between blood flow regulation and oxygen tensions in the functioning of endocrine systems, and the known regulatory signals involved in the modification of flow patterns under both normal physiological and pathological conditions.
机译:激素的脉动释放对于控制一系列重要的体内稳态功能是必不可少的。为了产生这些脉冲,内分泌器官已开发出精细调节的机制来调节血流,既可以满足与强烈的内分泌细胞活性相关的代谢需求,又可以确保分泌的激素在时间上精确地吸收到血液中。我们特别关注垂体作为模型系统,在此我们回顾了血流调节与氧气张力之间的相互作用在内分泌系统功能中的重要性,以及在两种正常情况下参与改变流型的已知调节信号生理和病理状况。

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