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首页> 外文期刊>The European Journal of Neuroscience >Pyrogenic cytokines injected into the rat cerebral ventricle induce cyclooxygenase-2 in brain endothelial cells and also upregulate their receptors.
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Pyrogenic cytokines injected into the rat cerebral ventricle induce cyclooxygenase-2 in brain endothelial cells and also upregulate their receptors.

机译：注入大鼠脑室的热原性细胞因子会诱导脑内皮细胞中的环氧合酶2并上调其受体。

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摘要

Peripheral immunological insults induce interleukin (IL)-1 beta and IL-6 in the brain. To elucidate the mechanism(s) of fever evoked by these brain-derived cytokines, and possible interactions between them, we examined in rats: (i) whether cyclooxygenase-2 is responsible for fever evoked by central injection of these cytokines; (ii) if so, where in the brain cyclooxygenase-2 is induced; (iii) where the receptors for these cytokines are located; and (iv) how the expression of these receptors is influenced by the cytokines. Intracerebroventricular injection of these cytokines evoked fever that was suppressed by a cyclooxygenase-2 inhibitor. Brain endothelium was the site of cyclooxygenase-2 induction by these cytokines. IL-1 receptor (IL-1R) was constitutively expressed in brain endothelium, and its mRNA was further upregulated by either cytokine. IL-6R mRNA was constitutively expressed in the cerebral cortex, and was newly induced in as yet unidentified cells in brain blood vessels by either cytokine. Messenger RNAs for cyclooxygenase-2, IL-1R, and IL-6R were often observed in the same blood vessels. These results suggest that COX-2 induced in brain endothelium is, at least in part, involved in the fever evoked by these cytokines, and that one possible interaction between these two cytokines is mutual upregulation of their receptors in the endothelium or perivascular cells, resulting in augmentation of their actions.
机译：外周免疫损伤在大脑中诱导白介素（IL）-1 beta和IL-6。为了阐明由这些脑源性细胞因子引起的发烧的机制以及它们之间可能的相互作用，我们在大鼠中进行了研究：（i）环氧合酶-2是否引起这些细胞因子的中心注射引起的发烧; （ii）如果是，在大脑中何处诱导产生环氧合酶-2; （iii）这些细胞因子受体的位置; （iv）这些受体的表达如何受到细胞因子的影响。脑室内注射这些细胞因子引起发烧，其被环氧合酶-2抑制剂抑制。脑内皮是这些细胞因子诱导环氧合酶2的位点。 IL-1受体（IL-1R）在脑内皮细胞中组成型表达，并且其mRNA被任一细胞因子进一步上调。 IL-6R mRNA在大脑皮层中组成性表达，并通过任一细胞因子在尚未识别的脑血管细胞中被新诱导。经常在同一血管中观察到环氧合酶2，IL-1R和IL-6R的Messenger RNA。这些结果表明，在脑内皮中诱导的COX-2至少部分地参与了这些细胞因子引起的发烧，并且这两种细胞因子之间的一种可能的相互作用是它们在内皮或血管周细胞中的受体相互上调，从而增强他们的行动。

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