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首页> 外文期刊>The European Journal of Neuroscience >Hippocampal-anterior thalamic pathways for memory: uncovering a network of direct and indirect actions.
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Hippocampal-anterior thalamic pathways for memory: uncovering a network of direct and indirect actions.

机译：海马-前丘脑的记忆途径：揭示直接和间接作用的网络。

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摘要

This review charts recent advances from a variety of disciplines that create a new perspective on why the multiple hippocampal-anterior thalamic interconnections are together vital for human episodic memory and rodent event memory. Evidence has emerged for the existence of a series of parallel temporal-diencephalic pathways that function in a reciprocal manner, both directly and indirectly, between the hippocampal formation and the anterior thalamic nuclei. These extended pathways also involve the mammillary bodies, the retrosplenial cortex and parts of the prefrontal cortex. Recent neuropsychological findings reveal the disproportionate importance of these hippocampal-anterior thalamic systems for recollective rather than familiarity-based recognition, while anatomical studies highlight the precise manner in which information streams are kept separate but can also converge at key points within these pathways. These latter findings are developed further by electrophysiological stimulation studies showing how the properties of the direct hippocampal-anterior thalamic projections are often opposed by the indirect hippocampal projections via the mammillary bodies to the thalamus. Just as these hippocampal-anterior thalamic interactions reflect an interdependent system, so it is also the case that pathology in one of the component sites within this system can induce dysfunctional changes to distal sites both directly and indirectly across the system. Such distal effects challenge more traditional views of neuropathology as they reveal how extensive covert pathology might accompany localised overt pathology, and so impair memory.
机译：这篇综述总结了来自各个学科的最新进展，这些学科为为什么多个海马-丘脑前部互连对人类的情节记忆和啮齿动物事件记忆起着至关重要的作用提供了新的观点。已有证据表明存在一系列平行的颞-脑间通路，这些通路在海马结构和丘脑前核之间直接或间接地以相互的方式起作用。这些延伸的途径还涉及乳头体，脾后皮质和前额叶皮质的一部分。最近的神经心理学发现揭示了这些海马-前丘脑系统对于回忆性识别（而非基于熟悉度的识别）的重要性不成比例，而解剖学研究强调了信息流保持分离但也可以在这些途径中的关键点收敛的精确方式。通过电生理刺激研究进一步证明了这些后发现，这些研究表明直接海马-丘脑前部投射的特性经常与经由乳头体到达丘脑的间接海马体投射相对。正如这些海马-前丘脑相互作用反映了一个相互依存的系统一样，该系统中一个组成部位的病理也可能导致整个系统直接或间接引起远端部位功能异常的改变。这种远端效应挑战了神经病理学的传统观点，因为它们揭示了广泛的隐秘病理可能与局部显性病理相伴，从而损害了记忆。

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