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首页> 外文期刊>The European Journal of Neuroscience >Spinal cord injury: taking a detour to recovery (Commentary on Schnell et al.).
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Spinal cord injury: taking a detour to recovery (Commentary on Schnell et al.).

机译:脊髓损伤:绕道康复(Schnell等人评论)。

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摘要

For years, the 'holy grail' of spinal cord injury research has been the attainment of long tract regeneration across the lesion site to provide reconnection of the brain with the motor and sensory centers of the completely severed cord. This goal has been more than elusive, but the few hints of success have usually involved the combination of several different therapeutic strategies aimed at the multiple barriers to regrowth and reconnection (e.g. Lu et al., 2004; Fouad et al, 2005; Bunge, 2008; Tom et al., 2009). The adult central nervous system expresses multiple inhibitory molecules that impede axonal elongation, including myelin proteins discovered by Martin Schwab and his group years ago (Schwab, 2004). Neurotrophic factors can be used to rev-up the latent growth capacities of adult neurons, and have been used with some success (e.g. Tom et al, 2009). In addition, even if axons can re-grow to reach their targets, they must form appropriate functional synapses in order to promote recovery.
机译:多年来,脊髓损伤研究的“圣杯”一直是在病变部位实现长线再生,以使大脑与完全切断的脊髓的运动和感觉中心重新连接。这个目标绝非易事,但成功的一些暗示通常涉及几种针对重生和重新连接的多重障碍的不同治疗策略的组合(例如Lu等,2004; Fouad等,2005; Bunge, 2008; Tom等,2009)。成年的中枢神经系统表达多种抑制轴突伸长的抑制性分子,包括马丁·施瓦布(Martin Schwab)及其同伙几年前发现的髓磷脂蛋白(Schwab,2004)。神经营养因子可用于提高成年神经元潜在的生长能力,并已获得成功(例如,Tom等,2009)。此外,即使轴突可以重新生长以达到其目标,它们也必须形成适当的功能突触才能促进恢复。

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