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首页> 外文期刊>The European Journal of Neuroscience >Primary food reward and reward-predictive stimuli evoke different patterns of phasic dopamine signaling throughout the striatum.
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Primary food reward and reward-predictive stimuli evoke different patterns of phasic dopamine signaling throughout the striatum.

机译：初级食物奖励和奖励预测刺激在整个纹状体中引起不同的阶段性多巴胺信号传导模式。

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摘要

Phasic changes in dopamine activity play a critical role in learning and goal-directed behavior. Unpredicted reward and reward-predictive cues evoke phasic increases in the firing rate of the majority of midbrain dopamine neurons--results that predict uniformly broadcast increases in dopamine concentration throughout the striatum. However, measurement of dopamine concentration changes during reward has cast doubt on this prediction. We systematically measured phasic changes in dopamine in four striatal subregions [nucleus accumbens shell and core (Core), dorsomedial (DMS) and dorsolateral striatum] in response to stimuli known to activate a majority of dopamine neurons. We used fast-scan cyclic voltammetry in awake and behaving rats, which measures changes in dopamine on a similar timescale to the electrophysiological recordings that established a relationship between phasic dopamine activity and reward. Unlike the responses of midbrain dopamine neurons, unpredicted food reward and reward-predictive cues evoked a phasic increase in dopamine that was subregion specific. In rats with limited experience, unpredicted food reward evoked an increase exclusively in the Core. In rats trained on a discriminative stimulus paradigm, both unpredicted reward and reward-predictive cues evoked robust phasic dopamine in the Core and DMS. Thus, phasic dopamine release in select target structures is dynamic and dependent on context and experience. Because the four subregions assayed receive different inputs and have differential projection targets, the regional selectivity of phasic changes in dopamine has important implications for information flow through the striatum and plasticity that underlies learning and goal-directed behavior.
机译：多巴胺活动的阶段性变化在学习和目标导向的行为中起着至关重要的作用。不可预测的奖励和奖励预测提示会引起大多数中脑多巴胺神经元放电频率的阶段性增加-结果预测整个纹状体中多巴胺浓度的均匀广播增加。然而，奖励期间多巴胺浓度变化的测量结果对该预测产生了怀疑。我们系统地测量了响应于激活大多数多巴胺神经元的刺激而在四个纹状体亚区域[伏伏核壳和核心（Core），背膜（DMS）和背外侧纹状体]中多巴胺的相变。我们在处于清醒状态和行为习惯的大鼠中使用了快速扫描循环伏安法，该伏安法在与建立生理性多巴胺活性和奖赏之间的关系的电生理记录相似的时间尺度上测量多巴胺的变化。与中脑多巴胺神经元的反应不同，不可预测的食物奖励和可预测奖励的提示会引起局部区域多巴胺的阶段性增加。在经验有限的大鼠中，无法预测的食物报酬引起了核心部位的增加。在接受有区别的刺激范式训练的大鼠中，不可预测的奖励和奖励预测提示均在核心和DMS中引起了稳健的相态多巴胺。因此，选择性目标结构中的多巴胺释放是动态的，并取决于环境和经验。由于所分析的四个子区域接收不同的输入并具有不同的投影目标，因此多巴胺的相变的区域选择性对于通过纹状体和可塑性的信息流具有重要意义，而纹状体和可塑性是学习和目标导向行为的基础。

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