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首页> 外文期刊>The European Journal of Neuroscience >Glucocorticoid-mediated nycthemeral and photoperiodic regulation of tph2 expression.
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Glucocorticoid-mediated nycthemeral and photoperiodic regulation of tph2 expression.

机译：糖皮质激素介导的tph2表达的夜尿和光周期调节。

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摘要

In the Syrian hamster dorsal and median raphe nuclei, the tryptophan hydroxylase 2 gene (tph2), which codes the rate-limiting enzyme of serotonin synthesis, displays daily variations in its expression in animals entrained to a long but not to a short photoperiod. The present study aimed to assess the role of glucocorticoids in the nycthemeral and photoperiodic regulation of daily tph2 expression. In hamsters held in long photoperiod from birth, after adrenalectomy and glucocorticoid implants the suppression of glucocorticoid rhythms induced an abolition of the daily variations in tph2-mRNA concentrations, a decrease in the amplitude of body temperature rhythms and an increase in testosterone levels. All these effects were reversed after experimental restoration of a clear daily rhythm in the plasma glucocorticoid concentrations. We conclude that the photoperiod-dependent rhythm of glucocorticoids is the main regulator of tph2 daily expression.
机译：在叙利亚仓鼠背侧和正中部缝核中，色氨酸羟化酶2基因（tph2）编码5-羟色胺合成的限速酶，在受长期但不短光周期的动物中表现出每日变化。本研究旨在评估糖皮质激素在每日tph2表达的夜间和光周期调节中的作用。在出生后长期处于光周期中的仓鼠中，肾上腺切除术和糖皮质激素植入后，糖皮质激素节律的抑制导致tph2-mRNA浓度的每日变化被消除，体温节律的幅度降低，睾丸激素水平增加。实验性恢复血浆糖皮质激素浓度的清晰每日节律后，所有这些作用均被逆转。我们得出结论，糖皮质激素的光周期依赖性节律是tph2日常表达的主要调节器。

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