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首页> 外文期刊>The European Journal of Neuroscience >Addition of fornix transection to frontal-temporal disconnection increases the impairment in object-in-place memory in macaque monkeys.
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Addition of fornix transection to frontal-temporal disconnection increases the impairment in object-in-place memory in macaque monkeys.

机译：额叶横断除额颞断开外，增加了猕猴的原位记忆能力。

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摘要

Both frontal-inferotemporal disconnection and fornix transection (Fx) in the monkey impair object-in-place scene learning, a model of human episodic memory. If the contribution of the fornix to scene learning is via interaction with or modulation of frontal-temporal interaction--that is, if they form a unitary system--then Fx should have no further effect when added to frontal-temporal disconnection. However, if the contribution of the fornix is to some extent distinct, then fornix lesions may produce an additional deficit in scene learning beyond that caused by frontal-temporal disconnection. To distinguish between these possibilities, we trained three male rhesus monkeys on the object-in-place scene-learning task. We tested their learning on the task following frontal-temporal disconnection, achieved by crossed unilateral aspiration of the frontal cortex in one hemisphere and the inferotemporal cortex in the other, and again following the addition of Fx. The monkeys were significantly impaired in scene learning following frontal-temporal disconnection, and furthermore showed a significant increase in this impairment following the addition of Fx, from 32.8% error to 40.5% error (chance = 50%). The increased impairment following the addition of Fx provides evidence that the fornix and frontal-inferotemporal interaction make distinct contributions to episodic memory.
机译：猴子的额颞下颞分离和穹横切（Fx）都会损害原位物体场景学习，这是人类情节记忆的模型。如果fornix对场景学习的贡献是通过与额颞互动的相互作用或调制的，即如果它们形成一个单一的系统，那么当将Fx添加到额颞断开时，Fx应该不再起作用。然而，如果穹隆的贡献在某种程度上是不同的，那么穹隆病变可能会在场景学习中产生额外的缺陷，而不仅仅是额颞断开。为了区分这些可能性，我们在现场对象现场学习任务中训练了三只雄性恒河猴。我们测试了他们在额颞分离后的任务学习情况，方法是通过一个半球的额叶皮层和另一个颞下叶皮层的交叉单侧抽吸，再加上Fx后再进行分离。额颞断开后，猴子的场景学习受到显着损害，此外，添加Fx后，这些损害也显着增加，从32.8％错误增加到40.5％错误（机会= 50％）。添加Fx后损伤增加，这提供了证据，即穹ni和额颞下部相互作用对情节记忆做出了独特的贡献。

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