...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The European Journal of Neuroscience >Depression-like behaviour in neural cell adhesion molecule (NCAM)-deficient mice and its reversal by an NCAM-derived peptide, FGL.
【24h】

Depression-like behaviour in neural cell adhesion molecule (NCAM)-deficient mice and its reversal by an NCAM-derived peptide, FGL.

机译：神经细胞粘附分子（NCAM）缺陷小鼠中的抑郁样行为，以及NCAM衍生肽FGL的逆转作用。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The neural cell adhesion molecule (NCAM) plays a pivotal role in brain plasticity. Brain plasticity itself has a crucial role in the development of depression. The aim of this study was to analyze whether NCAM-deficient (NCAM(-/-)) mice exhibit depression-like behaviour and whether a peptide termed FGL, derived from the NCAM binding site for the fibroblast growth factor (FGF) receptor, is able to reverse the depression-like signs in NCAM(-/-) mice. Our study showed that NCAM(-/-) mice demonstrated increased freezing time in the tail-suspension test and reduced preference for sucrose consumption in the sucrose preference test, reduced adult neurogenesis in the dentate gyrus and reduced levels of the phosphorylated cAMP response element-binding protein (pCREB) in the hippocampus. FGL administered acutely or repeatedly reduced depression-like behaviour in NCAM(-/-) mice without having an effect on their wild-type littermates. Repeated administration of FGL enhanced survival of the newly born neurons in NCAM(-/-) mice and increased the levels of pCREB in both NCAM(+/+) and NCAM(-/-) mice. In conclusion, our data demonstrate that NCAM deficiency in mice results in a depression-like phenotype which can be reversed by the acute or repeated administration of FGL. The results also suggest a role of the deficit in NCAM signalling through the FGF receptor in depression.
机译：神经细胞粘附分子（NCAM）在大脑可塑性中起关键作用。脑可塑性本身在抑郁症的发展中具有至关重要的作用。这项研究的目的是分析是否缺乏NCAM的（NCAM（-/-））小鼠表现出抑郁样的行为，以及是否衍生自成纤维细胞生长因子（FGF）受体NCAM结合位点的称为FGL的肽能够扭转NCAM（-/-）小鼠中的抑郁症样症状。我们的研究表明，NCAM（-/-）小鼠在尾部悬吊测试中显示了增加的冷冻时间，在蔗糖偏好测试中显示了对蔗糖消耗的偏好降低，在齿状回中减少了成年神经发生，并降低了磷酸化的cAMP反应元件-海马中的结合蛋白（pCREB）。 FGL急性或反复减少了NCAM（-/-）小鼠的抑郁样行为，而没有影响其野生型同窝仔。重复施用FGL可增强NCAM（-/-）小鼠中新生神经元的存活，并增加NCAM（+ / +）和NCAM（-/-）小鼠中pCREB的水平。总之，我们的数据表明，小鼠NCAM缺乏会导致抑郁样表型，急性或反复服用FGL可逆转这种表型。这些结果还表明，在抑郁症中，通过FGF受体的NCAM信号转导不足的作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号