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首页> 外文期刊>The European Journal of Neuroscience >Contextual integration the unusual way: a magnetoencephalographic study of responses to semantic violation in individuals with autism spectrum disorders.
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Contextual integration the unusual way: a magnetoencephalographic study of responses to semantic violation in individuals with autism spectrum disorders.

机译：上下文整合是一种不寻常的方式：对自闭症谱系障碍患者的语义违规做出反应的磁脑图研究。

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Autism is a neurodevelopmental disorder associated with deficits in language and social communication. Behavioural studies indicate abnormal semantic organization in individuals with autism, but little is known about the neural mechanism underlying the processing of language in context. Magnetoencephalography was used to record neural responses in 11 able adults with autism spectrum disorders reading meaningful sentences and sentences ending with a semantically incongruous word (e.g. 'He sent a photo to the trumpet'). Spatially extended evoked signals at 400 ms (N4) and 750 ms (LPC), as well as synchronized gamma-oscillations, provided clear evidence for specific neuronal processes sensitive to sentence context that differed in individuals with autism compared with typically developing individuals (11 healthy volunteers). Amongst other differences, N4 responses following incongruous words were weaker over left temporal cortices, whereas LPC responses to incongruous words and long-latency gamma-oscillations following congruous words were stronger over central and prefrontal regions in individuals with autism compared with the control group. Also, incongruous words elicited long-lasting gamma-oscillations above 40 Hz in the clinical group, but not in typically developing subjects. These findings may indicate unusual strategies for resolving semantic ambiguity in autism. Moreover, the observed gamma-band responses provide evidence for sustained cortical synchronization across segregated areas in individuals with autism, contrary to claims that a general deficit in either temporal binding or long-range connectivity may explain autism.
机译：自闭症是与语言和社交沟通不足相关的神经发育障碍。行为研究表明，自闭症患者的语义组织异常，但是对于在上下文中处理语言的神经机制知之甚少。磁脑描记术用于记录11名自闭症谱系障碍成年人的神经反应，这些成年人阅读有意义的句子和以语义不协调的单词结尾的句子（例如，``他向小号发送了一张照片''）。在400 ms（N4）和750 ms（LPC）处的空间扩展诱发信号，以及同步的伽马振荡，为特定的对句子上下文敏感的神经元过程提供了明确的证据，自闭症患者与一般发育中的个体相比，这些神经元过程有所不同（11位健康志愿者）。除其他差异外，自闭症患者对中枢和前额叶区域的不协调词对N4的反应在左颞皮层较弱，而对不协调词和LPC对不协调词的反应较中枢和前额叶区域强。同样，在临床组中，不协调的单词会引起40 Hz以上的持久伽马振荡，但在正常发育的受试者中则不会。这些发现可能表明解决自闭症语义歧义的不寻常策略。此外，观察到的伽马波段反应提供了自闭症个体在隔离区域内持续皮层同步的证据，这与声称暂时性结合或远距离连通性普遍不足可以解释自闭症的说法相反。

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