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首页> 外文期刊>The European Journal of Neuroscience >Cortical serotonin and norepinephrine denervation in parkinsonism: preferential loss of the beaded serotonin innervation.
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Cortical serotonin and norepinephrine denervation in parkinsonism: preferential loss of the beaded serotonin innervation.

机译：帕金森病中的皮质5-羟色胺和去甲肾上腺素的去神经作用：珠状5-羟色胺神经支配的优先丧失。

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Parkinson's Disease (PD) is marked by prominent motor symptoms that reflect striatal dopamine insufficiency. However, non-motor symptoms, including depression, are common in PD. It has been suggested that these changes reflect pathological involvement of non-dopaminergic systems. We examined regional changes in serotonin (5-HT) and norepinephrine (NE) systems in mice treated with two different 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment paradigms, at survival times of 3 or 16 weeks after the last MPTP injection. MPTP caused a decrease in striatal dopamine concentration, the magnitude of which depended on the treatment regimen and survival interval after MPTP treatment. There was significant involvement of other subcortical areas receiving a dopamine innervation, but no consistent changes in 5-HT or NE levels in subcortical sites. In contrast, we observed an enduring decrease in 5-HT and NE concentrations in both the somatosensory cortex and medial prefrontal cortex (PFC). Immunohistochemical studies also revealed a decrease in the density of PFC NE and 5-HT axons. The decrease in the cortical serotonergic innervation preferentially involved the thick beaded but not smooth fine 5-HT axons. Similar changes in the 5-HT innervation of post-mortem samples of the PFC from idiopathic PD cases were seen. Our findings point to a major loss of the 5-HT and NE innervations of the cortex in MPTP-induced parkinsonism, and suggest that loss of the beaded cortical 5-HT innervation is associated with a predisposition to the development of depression in PD.
机译：帕金森氏病（PD）的特征是明显的运动症状，反映出纹状体多巴胺不足。但是，PD中常见非运动性症状，包括抑郁。已经提出这些变化反映了非多巴胺能系统的病理学参与。我们检查了在两种小鼠的存活时间分别为1种甲基4-苯基-1,2,3,6-四氢吡啶（MPTP）治疗范例的小鼠中血清素（5-HT）和去甲肾上腺素（NE）系统的区域变化最后一次MPTP注射后3或16周。 MPTP导致纹状体多巴胺浓度降低，其幅度取决于MPTP治疗后的治疗方案和生存间隔。接受多巴胺神经支配的其他皮层下区域也有明显的参与，但是皮层下部位的5-HT或NE水平没有持续变化。相反，我们在体感皮层和内侧前额叶皮层（PFC）中均观察到5-HT和NE浓度持续下降。免疫组织化学研究还显示PFC NE和5-HT轴突的密度降低。皮质血清素能神经支配的减少优先涉及厚珠，但不光滑的5-HT轴突。在特发性PD病例的PFC验尸样品的5-HT神经支配中观察到类似变化。我们的发现指出在MPTP诱发的帕金森病中，皮质的5-HT和NE神经支配的大量丧失，并提示珠状皮质5-HT神经支配的丧失与PD抑郁症发展的易感性有关。

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