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首页> 外文期刊>The European Journal of Neuroscience >Population coding of tone stimuli in auditory cortex: dynamic rate vector analysis.
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Population coding of tone stimuli in auditory cortex: dynamic rate vector analysis.

机译：听觉皮层声调刺激的人口编码：动态速率矢量分析。

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Neural representations of even temporally unstructured stimuli can show complex temporal dynamics. In many systems, neuronal population codes show 'progressive differentiation', whereby population responses to different stimuli grow further apart during a stimulus presentation. Here we analysed the response of auditory cortical populations in rats to extended tones. At onset (up to 300 ms), tone responses involved strong excitation of a large number of neurons; during sustained responses (after 500 ms) overall firing rate decreased, but most cells still showed statistically significant rate modulation. Population vector trajectories evoked by different tone frequencies expanded rapidly along an initially similar trajectory in the first tens of milliseconds after tone onset, later diverging to smaller amplitude fixed points corresponding to sustained responses. The angular difference between onset and sustained responses to the same tone was greater than between different tones in the same stimulus epoch. No clear orthogonalization of responses was found with time, and predictability of the stimulus from population activity also decreased during this period compared with onset. The question of whether population activity grew more or less sparse with time depended on the precise mathematical sense given to this term. We conclude that auditory cortical population responses to tones differ from those reported in many other systems, with progressive differentiation not seen for sustained stimuli. Sustained acoustic stimuli are typically not behaviorally salient: we hypothesize that the dynamics we observe may instead allow an animal to maintain a representation of such sounds, at low energetic cost.
机译：甚至时间上非结构化的刺激的神经表示也可以显示复杂的时间动态。在许多系统中，神经元种群代码显示出“渐进式分化”，从而在刺激表现期间，对不同刺激的种群反应进一步分开。在这里，我们分析了大鼠听觉皮层人口对扩展音调的反应。发作时（最长300毫秒），音调反应涉及大量神经元的强烈激发。在持续响应（500毫秒后）期间，总体发射速率降低，但大多数细胞仍显示出统计学上显着的速率调节。由不同音调频率引起的总体矢量轨迹在音调开始后的最初几十毫秒内沿着初始相似的轨迹迅速扩展，随后发散到与持续响应相对应的较小幅度固定点。在相同刺激时期，对相同音调的开始和持续反应之间的角度差异要大于在不同音调之间的差异。与时间相比，没有发现响应随时间呈明显的正交关系，并且在此期间，来自种群活动的刺激的可预测性也降低了。人口活动是否随时间增长稀疏的问题取决于该术语的精确数学意义。我们得出的结论是，听觉皮层人口对音调的反应与许多其他系统中报道的反应不同，持续性刺激未见到进行性分化。持续的声刺激通常在行为上并不明显：我们假设观察到的动力学可以使动物以低昂的精力维持这种声音的表现。

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