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首页> 外文期刊>The European Journal of Neuroscience >Interference of working memory load with long-term memory formation.
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Interference of working memory load with long-term memory formation.

机译：工作内存负载对长期内存形成的干扰。

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Traditionally, it has been assumed that the medial temporal lobe (MTL) is indispensable for long-term memory (LTM) encoding, but only plays a minor role for working memory (WM) maintenance. Recently, however, an increasing number of studies questioned this seemingly clear distinction by showing that the MTL does participate in some WM processes, especially if multiple items are being maintained. This would predict that WM maintenance of multiple items interferes with simultaneous LTM encoding. Here, we tested this idea in a functional magnetic resonance imaging paradigm that required subjects to encode stimuli into LTM during simultaneous WM maintenance of either single or multiple items. Indeed, we found that maintenance of multiple items deteriorates simultaneous LTM encoding as compared with maintenance of single items. WM-related activation of the hippocampus was more pronounced in the condition with high WM load; in contrast, hippocampal activation related to LTM encoding was stronger in the low WM load condition. Successful LTM encoding was associated with a high level of activity in the adjacent parahippocampal cortex (PHC), leading to pronounced parahippocampal subsequent memory effects in the high load condition. This suggests that the PHC is a locus of WM-LTM interaction. Functional connectivity analysis with a seed in the PHC confirmed this result by revealing strong connectivity with the medial frontal cortex, which was only active in the high WM load condition. Taken together, these findings suggest that high WM demands interfere with LTM encoding and thus support the idea that WM and LTM processes interact in the MTL.
机译：传统上，已经假设内侧颞叶（MTL）对于长期记忆（LTM）编码是必不可少的，但是对于工作记忆（WM）维护仅起次要作用。但是，最近，越来越多的研究通过证明MTL确实参与了某些WM流程，尤其是在维护多个项目的情况下，对这种看似明显的区别提出了质疑。这可以预测WM对多个项目的维护会干扰同时的LTM编码。在这里，我们在功能磁共振成像范例中测试了这个想法，该范例要求受试者在同时维护单个或多个项目的WM期间将刺激编码为LTM。的确，我们发现，与维护单个项目相比，维护多个项目会使同时进行的LTM编码恶化。在高WM负荷的情况下，与WM相关的海马激活更为明显。相反，在低WM负荷条件下，与LTM编码相关的海马激活更强。成功的LTM编码与邻近海马旁皮质（PHC）的高水平活性相关，从而导致在高负荷条件下明显的海马旁记忆效应。这表明PHC是WM-LTM相互作用的一个场所。在PHC中使用种子进行功能连接性分析，通过揭示与内侧额叶皮层的强连接性（仅在高WM负载条件下才有效）证实了这一结果。综上所述，这些发现表明，高WM需求会干扰LTM编码，因此支持WM和LTM流程在MTL中交互的想法。

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