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首页> 外文期刊>The European Journal of Neuroscience >Roles of opioid receptor subtypes in mediating alcohol-seeking induced by discrete cues and context.
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Roles of opioid receptor subtypes in mediating alcohol-seeking induced by discrete cues and context.

机译：阿片受体亚型在介导离散线索和环境诱导的寻求酒精中的作用。

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The aim of this study was to assess the effects of selective blockade of the delta (DOP) or mu (MOP) opioid receptors on alcohol-seeking induced by discrete cues and context. In Experiment 1, rats were trained to self-administer alcohol in an environment with distinct sensory properties. After extinction in a different context with separate sensory properties, rats were tested for context-induced renewal in the original context following treatment with the DOP receptor antagonist naltrindole (0-15 mg/kg, i.p.) or the MOP receptor antagonist D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH(2) (CTOP) (0-3 microg/4 microL, i.c.v.). In Experiment 2, reinstatement was tested with the presentation of a discrete light + tone cue previously associated with alcohol delivery, following extinction without the cue. The effects of naltrindole (0-5 mg/kg, i.p.) or CTOP (0-3 microg/4 microL, i.c.v.) were assessed. For context-induced renewal, 7.5 mg/kg naltrindole reduced responding without affecting locomotor activity. Both doses of CTOP attenuated responding in the first 15 min of the renewal test session; however, total responses did not differ at the end of the session. For discrete-cue-induced reinstatement, 1 and 5 mg/kg naltrindole attenuated responding but CTOP had no effect. We conclude that whereas DOP receptors mediate alcohol-seeking induced by discrete cues and context, MOP receptors may play a modest role only in context-induced renewal. These findings point to a differential involvement of opioid receptor subtypes in the effects of different kinds of conditioned stimuli on alcohol-seeking and support a more prominent role for DOP receptors.
机译：这项研究的目的是评估选择性阻断δ（DOP）或μ（MOP）阿片受体对离散线索和环境诱导的寻求酒精的影响。在实验1中，训练了大鼠在具有独特感官特性的环境中自我给药酒精。在具有不同感觉特性的不同环境中灭绝后，在用DOP受体拮抗剂纳那多尔（0-15 mg / kg，ip）或MOP受体拮抗剂D-Phe- Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH（2）（CTOP）（0-3 microg / 4 microL，icv）。在实验2中，在没有提示的情况下将其熄灭后，通过显示先前与酒精输送相关的离散的灯光+提示提示来测试恢复情况。评估了纳曲酮（0-5 mg / kg，i.p.）或CTOP（0-3 microg / 4 microL，i.c.v.）的作用。对于情境诱导的更新，7.5 mg / kg的萘并吲哚减少了响应，而不会影响运动活性。在更新测试阶段的前15分钟，两种剂量的CTOP均减弱了响应;但是，总的答复在会议结束时没有不同。对于离散提示诱导的恢复，1和5 mg / kg的纳曲酮减弱了响应，但CTOP没有作用。我们得出的结论是，尽管DOP受体介导了离散线索和情境引起的寻求酒精，但MOP受体仅在情境引起的更新中可能起适度的作用。这些发现表明阿片样物质受体亚型在不同种类的条件刺激对寻求酒精的影响中有不同的参与，并支持DOP受体发挥更重要的作用。

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