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首页> 外文期刊>The European Journal of Neuroscience >TRPA1-mediated responses in trigeminal sensory neurons: interaction between TRPA1 and TRPV1.
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TRPA1-mediated responses in trigeminal sensory neurons: interaction between TRPA1 and TRPV1.

机译：三叉神经感觉神经元中TRPA1介导的反应：TRPA1和TRPV1之间的相互作用。

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摘要

The transient receptor potential (TRP)A1 channel is involved in the transduction of inflammation-induced noxious stimuli from the periphery. Previous studies have characterized the properties of TRPA1 in heterologous expression systems. However, there is little information on the properties of TRPA1-mediated currents in sensory neurons. A capsaicin-sensitive subset of rat and mouse trigeminal ganglion sensory neurons was activated with TRPA1-specific agonists, mustard oil and the cannabinoid WIN55,212. Mustard oil- and WIN55,212-gated currents exhibited marked variability in their kinetics of activation and acute desensitization. TRPA1-mediated responses in neurons also possess a characteristic voltage dependency with profound outward rectification that is influenced by extracellular Ca(2+) and the type and concentration of TRPA1-specific agonists. Examination of TRPA1-mediated responses in TRPA1-containing cells indicated that the features of neuronal TRPA1 are not duplicated in cells expressing only TRPA1 and, instead, can be restored only when TRPA1 and TRPV1 channels are coexpressed. In summary, our results suggest that TRPA1-mediated responses in sensory neurons have distinct characteristics that can be accounted for by the coexpression of the TRPV1 and TRPA1 channels.
机译：瞬时受体电位（TRP）A1通道参与了炎症诱导的有害刺激从周围的转导。先前的研究已经表征了TRPA1在异源表达系统中的特性。但是，关于感觉神经元中TRPA1介导的电流的性质的信息很少。大鼠和小鼠三叉神经节感觉神经元的辣椒素敏感子集被TRPA1特异性激动剂，芥子油和大麻素WIN55,212激活。芥菜油和WIN55,212门控电流在其激活和急性脱敏动力学方面表现出明显的可变性。 TRPA1介导的反应在神经元中也具有特征性的电压依赖性，具有深远的外部整流作用，受到细胞外Ca（2+）以及TRPA1特异性激动剂的类型和浓度的影响。在含有TRPA1的细胞中检查TRPA1介导的反应表明，神经元TRPA1的特征在仅表达TRPA1的细胞中没有重复，相反，只有在TRPA1和TRPV1通道共表达时才能恢复。总而言之，我们的结果表明，感觉神经元中TRPA1介导的反应具有独特的特征，可以通过TRPV1和TRPA1通道的共表达来解释。

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