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首页> 外文期刊>The European Journal of Neuroscience >Homeostatic plasticity in a reward processing region: accumbens neurons scale too! (Commentary on Sun & Wolf).
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Homeostatic plasticity in a reward processing region: accumbens neurons scale too! (Commentary on Sun & Wolf).

机译：奖赏处理区域的稳态可塑性：伏隔神经元也可扩展！ （关于太阳与狼的评论）。

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摘要

There is an expanding literature that supports the idea that several aspects of addiction to drugs of abuse are behavioral expressions of pathological forms of learning and memory coded in brain circuits involved in reward processing. At a cellular level, it has now been well demonstrated that several drugs of abuse interfere with synaptic plasticity mechanisms in reward regions and thereby influence their function (Wolfe? al., 2004; Kauer & Malenka, 2007).In this context, it is relevant to emphasize that whereas LTP and LTD, the two most studied forms of synaptic plasticity, are widely viewed as cellular models of learning and memory, it is also well appreciated that their implementation in neuronal network models carries an inherent stability problem (Turrigiano, 2008). The phenomenon of homeostatic synaptic scaling (O'Brien et al, 1998; Turrigiano et al, 1998) satisfactorily solves many of the issues related to this problem and has thus triggered considerable interest This plasticity refers to the bi-directional ability of the overall synaptic strength of a neuron to actively compensate for changes in overall excitability levels, presumably to maintain firing rates within an optimal range (Davis, 2006; Turrigiano, 2008).
机译：越来越多的文献支持以下观点：滥用药物成瘾的几个方面是在奖励处理所涉及的大脑回路中编码的学习和记忆的病理形式的行为表达。在细胞水平上，现已充分证明，几种滥用药物会干扰奖励区域的突触可塑性机制，从而影响其功能（Wolfe？al。，2004; Kauer＆Malenka，2007）。有关强调的是，虽然LTP和LTD是研究最多的两种突触可塑性形式，被广泛视为学习和记忆的细胞模型，但也应充分认识到，它们在神经元网络模型中的实施存在固有的稳定性问题（Turrigiano，2008年） ）。稳态突触缩放的现象（O'Brien等，1998; Turrigiano等，1998）令人满意地解决了与此问题相关的许多问题，因此引起了极大的兴趣。可塑性是指整个突触的双向能力神经元的强度，可以主动补偿总体兴奋性水平的变化，大概是将放电频率维持在最佳范围内（Davis，2006; Turrigiano，2008）。

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