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首页> 外文期刊>The European Journal of Neuroscience >Critical role of insular cortex in taste but not odour aversion memory.
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Critical role of insular cortex in taste but not odour aversion memory.

机译：岛叶皮层在味觉而不是气味厌恶记忆中的关键作用。

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摘要

Conditioned odour aversion (COA) and conditioned taste aversion (CTA) result from the association of a novel odour or a novel taste with delayed visceral illness. The insular cortex (IC) is crucial for CTA memory, and the present experiments sought to determine whether the IC is required for the formation and the retrieval of COA memory as it is for CTA. We first demonstrated that ingested odour is as effective as taste for single-trial aversion learning in rats conditioned in their home cage. COA, like CTA, tolerates long intervals between the ingested stimuli and the illness and is long-lasting. Transient inactivation of the IC during acquisition spared COA whereas it greatly impaired CTA. Similarly, blockade of protein synthesis in IC did not affect COA but prevented CTA consolidation. Moreover, IC inactivation before retrieval tests did not interfere with COA memory expression when performed either 2 days (recent memory) or 36 days after acquisition (remote memory). Similar IC inactivation impairedthe retrieval of either recent or remote CTA memory. Altogether these findings indicate that the IC is not necessary for aversive odour memory whereas it is essential for acquisition, consolidation and retrieval of aversive taste memory. We propose that the chemosensory stimulations modulate IC recruitment during the formation and the retrieval of food aversive memory.
机译：有条件的气味厌恶（COA）和有条件的气味厌恶（CTA）是由于新气味或新口味与内脏疾病的延迟相关。岛叶皮层（IC）对于CTA记忆至关重要，本实验试图确定IC是否是形成CTA和恢复COA记忆所必需的。我们首先证明了摄取的气味与在家笼中饲养的大鼠的单次厌恶学习一样有效。像CTA一样，COA可以忍受摄入的刺激物和疾病之间的较长间隔，并且是持久的。采集期间IC的瞬态失活可以节省COA，但会大大削弱CTA。同样，在IC中阻止蛋白质合成不会影响COA，但会阻止CTA合并。此外，检索测试前2天（最近的记忆）或采集后36天（远程记忆）进行的IC失活都不会干扰COA记忆的表达。类似的IC失活会损害对最近或远程CTA存储器的检索。总而言之，这些发现表明IC对于厌恶的气味记忆不是必需的，而对于厌恶的味觉记忆的获取，巩固和恢复是必不可少的。我们提出化学感应刺激调节食物厌恶记忆的形成和恢复过程中的IC募集。

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