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首页> 外文期刊>The European Journal of Neuroscience >Deep brain stimulation for the treatment of vegetative state.
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Deep brain stimulation for the treatment of vegetative state.

机译：深部脑刺激，用于治疗植物生长状态。

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One hundred and seven patients in vegetative state (VS) were evaluated neurologically and electrophysiologically over 3 months (90 days) after the onset of brain injury. Among these patients, 21 were treated with deep brain stimulation (DBS). The stimulation sites were the mesencephalic reticular formation (two patients) and centromedian-parafascicularis nucleus complex (19 cases). Eight of the patients recovered from VS and were able to obey verbal commands at 13 and 10 months in the case of head trauma and at 19, 14, 13, 12, 12 and 8 months in the case of vascular disease after comatose brain injury, and no patients without DBS recovered from VS spontaneously within 24 months after brain injury. The eight patients who recovered from VS showed desynchronization on continuous EEG frequency analysis. The Vth wave of the auditory brainstem response and N20 of the somatosensory evoked potential could be recorded, although with a prolonged latency, and the pain-related P250 was recorded with an amplitude of > 7 muV. Sixteen (14.9%) of the 107 VS patients satisfied these criteria in our electrophysiological evaluation, 10 of whom were treated with DBS and six of whom were not treated with DBS. In these 16 patients, the recovery rate from VS was different between the DBS therapy group and the no DBS therapy group (P < 0.01, Fisher's exact probability test) These findings indicate that DBS may be useful for the recovery of patients from VS if the candidates are selected on the basis of electrophysiological criteria.
机译：在脑损伤发作后的3个月（90天）内，对107名处于营养状态（VS）的患者进行了神经和电生理学评估。在这些患者中，有21名接受了深部脑刺激（DBS）治疗。刺激部位为中脑网状结构（2例）和着丝粒体-束旁束核复合体（19例）。其中有八名患者从VS中康复，在头部外伤的情况下，在13和10个月时服从语言命令;在昏迷性脑损伤后的血管疾病中，在19、14、13、12、12和8个月时服从语言命令，脑损伤后24个月内，没有DBS的患者没有自发地从VS恢复。从VS恢复的8例患者在连续脑电图频率分析中显示出失步。尽管潜伏期延长，但可以记录到听觉脑干反应的Vth波和体感诱​​发电位的N20，并且记录了与疼痛有关的P250，振幅> 7 muV。 107名VS患者中有16名（14.9％）在我们的电生理评估中满足了这些标准，其中10名接受DBS治疗，其中6名未经DBS治疗。在这16例患者中，DBS治疗组和非DBS治疗组之间VS的恢复率有所不同（P <0.01，Fisher精确概率检验）。这些发现表明，DBS可能有助于从VS康复的患者。根据电生理标准选择候选人。

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