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首页> 外文期刊>The European Journal of Neuroscience >The intimate relationship of gonadotropin-releasing hormone neurons with the polysialylated neural cell adhesion molecule revisited across development and adult plasticity.
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The intimate relationship of gonadotropin-releasing hormone neurons with the polysialylated neural cell adhesion molecule revisited across development and adult plasticity.

机译：促性腺激素释放激素神经元与多唾液酸化神经细胞粘附分子的亲密关系在发育和成人可塑性中得到了重新探讨。

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摘要

The neurohormone gonadotropin-releasing hormone (GnRH) is critical for all the aspects of reproductive life in vertebrates. GnRH is secreted by a small number of neurons dispersed within the preoptic-hypothalamic region. These neurons are derived from the embryonic olfactory pit. They then migrate along olfactory, vomeronasal and terminal nerves to their final destination. Classical approaches to study the regulation of GnRH secretion during the reproductive cycle have focused on the various neuronal inputs on GnRH neurons and their regulation by ovarian steroids. However, it is well known that steroids will change the microenvironment of neuronal networks and can induce plasticity and functional changes. In this review, we will focus on the intimate relationship of developing and adult GnRH neurons with the polysialylated form of neural cell adhesion molecule (PSA-NCAM), a major molecular actor in the morphogenesis and adult plasticity of the nervous system. We will first recapitulate the spatiotemporal relationship between PSA-NCAM and migrating GnRH neurons during embryogenesis of various vertebrate species and discuss its importance for GnRH neuron development as shown by various loss of function studies. In the adult, we will review the relationships between PSA-NCAM and GnRH neurons across various physiological states, and open the discussion to the use of new model systems that can help to unravel the function and mechanism of action of PSA-NCAM on GnRH neuronal network activity and GnRH release.
机译：神经激素促性腺激素释放激素（GnRH）对于脊椎动物生殖生活的各个方面都至关重要。 GnRH是由散布在视前下丘脑区域内的少量神经元分泌的。这些神经元来自胚胎嗅觉窝。然后，它们沿着嗅觉，犁鼻和末梢神经迁移到最终目的地。研究生殖周期中GnRH分泌调控的经典方法集中于GnRH神经元的各种神经元输入及其通过卵巢类固醇的调控。但是，众所周知，类固醇会改变神经元网络的微环境，并会诱导可塑性和功能变化。在这篇综述中，我们将重点关注发育中和成年的GnRH神经元与神经细胞粘附分子（PSA-NCAM）的多唾液酸化形式的密切关系，后者是神经系统形态发生和成年可塑性的主要分子。我们将首先概述各种脊椎动物物种胚胎发生过程中PSA-NCAM与迁移的GnRH神经元之间的时空关系，并讨论其对GnRH神经元发育的重要性，如各种功能丧失研究所示。在成年人中，我们将回顾各种生理状态下PSA-NCAM与GnRH神经元之间的关系，并开始讨论使用新的模型系统，以帮助阐明PSA-NCAM对GnRH神经元的功能和作用机制。网络活动和GnRH发布。

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