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首页> 外文期刊>The European Journal of Neuroscience >Passive vs. active touch-induced activity in the developing whisker pathway.
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Passive vs. active touch-induced activity in the developing whisker pathway.

机译：晶须途径中的被动与主动触摸感应活动。

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摘要

The mouse trigeminal (V) system undergoes significant postnatal structural and functional developmental changes. Histological modules (barrelettes, barreloids and barrels) in the brainstem, thalamus and cortex related to actively moved (whisking) tactile hairs (vibrissae) on the face allow detailed studies of development. High-resolution [(3) H]2-deoxyglucose (2DG) emulsion autoradiography with cytochrome oxidase histochemistry was used to analyze neuronal activity changes related to specific whisker modules in the developing and mature mouse V system provoked by passive (experimenter-induced) and active (animal-induced) displacements of a single whisker (D4). We tested the hypothesis that neuronal activity patterns change in relation to the onset of active touch (whisking) on postnatal day (P)14. Quantitative image analyses revealed: (i) on P7, when whisker-like patterns of modules are clear, heightened 2DG activity in all appropriate modules in the brainstem, thalamus and cortex; (ii) on P14, a transitory activity pattern coincident with the emergence of whisking behavior that presages (iii) strong labeling of the spinal V subnucleus interpolaris and barrel cortex produced by single-whisker-mediated active touch in adults and (iv) at all above-listed ages and structures, significant suppression of baseline activity in some modules surrounding those representing the stimulated whisker. Differences in activity patterns before and after the onset of whisking behavior may be caused by neuronal activity induced by whisking, and by strengthening of modulatory projections that alter the activity of subcortical inputs produced by whisking behavior during active touch.
机译：小鼠三叉戟（V）系统发生重大的产后结构和功能发育变化。脑干，丘脑和皮层中与面部主动移动（胡须）触觉毛发（触须）相关的组织学模块（发夹，桶状和桶状）可以对发育进行详细研究。高分辨率[（3）H] 2-脱氧葡萄糖（2DG）乳腺放射自显影与细胞色素氧化酶组织化学用于分析与被动（实验者诱发）和诱发的发育中和成熟小鼠V系统中特定晶须模块相关的神经元活性变化。晶须（D4）的主动（动物引起的）位移。我们测试了这样的假设：在产后一天（P）14，神经元活动模式与活动性接触（耳鸣）的发生有关。定量图像分析显示：（i）在P7上，当晶须状晶须模式清晰时，脑干，丘脑和皮质中所有适当模块中的2DG活性增强; （ii）在P14上，短暂的活动模式与出现的搅拌行为相吻合，预示着（iii）成人由单晶须介导的主动触摸产生的脊髓V亚核间质和桶状皮层的强烈标记，以及（iv）完全以上列出的年龄和结构，在代表受激晶须的模块周围的某些模块中，基线活动的显着抑制。搅拌行为发生之前和之后，活动模式的差异可能是由搅拌引起的神经元活动，以及通过增强调节性投射所致，这些调制性投射会改变主动触摸过程中由搅拌行为产生的皮层下输入的活动。

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