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首页> 外文期刊>The European Journal of Neuroscience >Contribution of the central thalamus to the generation of volitional saccades.
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Contribution of the central thalamus to the generation of volitional saccades.

机译：中央丘脑对自愿性扫视的产生。

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Lesions in the motor thalamus can cause deficits in somatic movements. However, the involvement of the thalamus in the generation of eye movements has only recently been elucidated. In this article, we review recent advances into the role of the thalamus in eye movements. Anatomically, the anterior group of the intralaminar nuclei and paralaminar portion of the ventrolateral, ventroanterior and mediodorsal nuclei of the thalamus send massive projections to the frontal eye field and supplementary eye field. In addition, these parts of the thalamus, collectively known as the 'oculomotor thalamus', receive inputs from the cerebellum, the basal ganglia and virtually all stages of the saccade-generating pathways in the brainstem. In their pioneering work in the 1980s, Schlag and Schlag-Rey found a variety of eye movement-related neurons in the oculomotor thalamus, and proposed that this region might constitute a 'central controller' playing a role in monitoring eye movements and generating self-paced saccades. This hypothesis has been evaluated by recent experiments in non-human primates and by clinical observations of subjects with thalamic lesions. In addition, several recent studies have also addressed the involvement of the oculomotor thalamus in the generation of anti-saccades and the selection of targets for saccades. These studies have revealed the impact of subcortical signals on the higher-order cortical processing underlying saccades, and suggest the possibility of future studies using the oculomotor system as a model to explore the neural mechanisms of global cortico-subcortical loops and the neural basis of a local network between the thalamus and cortex.
机译：运动丘脑中的病变可导致躯体运动不足。然而，直到最近才阐明丘脑参与眼球运动的产生。在本文中，我们回顾了丘脑在眼球运动中的作用的最新进展。从解剖学上讲，丘脑腹外侧，腹侧前腹和中间气味核的板层内核和板层旁部分的前组向前眼区和补充眼区发送大量投影。此外，丘脑的这些部分统称为“动眼丘脑”，接受小脑，基底神经节以及脑干中扫视产生途径的所有阶段的输入。 Schlag和Schlag-Rey在1980年代的开创性工作中，在动眼丘脑中发现了多种与眼动相关的神经元，并提出该区域可能构成“中央控制器”，在监视眼动和产生自我视觉上发挥作用。节奏扫视。通过最近在非人类灵长类动物中的实验以及对患有丘脑病变的受试者的临床观察，对该假设进行了评估。此外，最近的一些研究还讨论了动眼丘脑参与反扫视的产生和扫视靶标的选择。这些研究揭示了皮层下信号对扫视的高阶皮层加工的影响，并暗示了未来可能使用动眼动系统作为模型探索整体皮层-皮层下回路的神经机制和神经皮质基础的研究。丘脑和皮质之间的局部网络。

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