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首页> 外文期刊>The European Journal of Neuroscience >Synaptic and intrinsic mechanisms shape synchronous oscillations in hippocampal neurons in culture.
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Synaptic and intrinsic mechanisms shape synchronous oscillations in hippocampal neurons in culture.

机译：突触和内在机制塑造文化海马神经元的同步振荡。

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摘要

We have detected spontaneous, synchronous calcium oscillations, associated with variations in membrane potential, in hippocampal neurons maintained in primary culture. The oscillatory activity is synaptically driven, as it is blocked by tetrodotoxin, by the glutamate receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and by toxins inhibiting neurotransmitter release from presynaptic nerve endings. Neuronal oscillations do not require for their expression the presence of a polyneuronal network and are not primarily influenced by the gamma-aminobutyric acid (GABA(A)) receptor antagonist picrotoxin, suggesting that they entirely rely on glutamatergic neurotransmission. Synaptic and intrinsic conductances shape the synchronized oscillations in hippocampal neurons. The concomitant activation of N-methyl-D-aspartate (NMDA) receptors and voltage-activated L-type calcium channels allows calcium entering from the extracellular medium and sustaining the long depolarization, which shapes every single calcium wave.
机译：我们已经在原代培养的海马神经元中检测到自发的，同步的钙振荡，与膜电位的变化有关。振荡活性由突触毒素，谷氨酸受体拮抗剂6-氰基-7-硝基喹喔啉-2,3-二酮（CNQX）和抑制突触前神经末梢释放神经递质的毒素来突触驱动。神经元振荡不需要表达即可表达多神经网络，且不受γ-氨基丁酸（GABA（A））受体拮抗剂微毒素的主要影响，表明它们完全依赖于谷氨酸能神经传递。突触和内在电导塑造海马神经元的同步振荡。 N-甲基-D-天门冬氨酸（NMDA）受体和电压激活的L型钙通道的同时激活，使钙从细胞外介质进入并维持长时间的去极化，从而形成每个钙波。

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