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首页> 外文期刊>The European Journal of Neuroscience >c-Jun expression after axotomy of corneal trigeminal ganglion neurons is dependent on the site of injury.
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c-Jun expression after axotomy of corneal trigeminal ganglion neurons is dependent on the site of injury.

机译：角膜三叉神经节神经元轴突切开后的c-Jun表达取决于损伤部位。

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摘要

The proto-oncogene c-Jun has been implicated in the control of neuronal responses to injury and in axonal growth during regenerative processes. We have investigated the expression of c-Jun during normal terminal remodelling in trigeminal ganglion neurons innervating the cornea and after acute injury of epithelial nerve terminals or parent axons. Remodelling and rearrangement, or damage limited to corneal epithelium endings, was not a trigger for activation of c-Jun expression. However, injury of parent axons in the stroma or in the orbital ciliary nerves induced c-Jun expression in 50% of the population of corneal neurons, which included all of the large myelinated and 20% of the small neuropeptide-containing corneal neurons. This suggests that c-Jun expression in trigeminal ganglion neurons is not associated with normal remodelling or regeneration of peripheral nerve terminals, and that it takes place only when parent axons are injured. A substantial number of damaged neurons do not express c-Jun, indicating that in primary sensory neurons, injury and regeneration may not always be coupled to the expression of this proto-oncogene.
机译：原癌基因c-Jun参与了神经元对损伤的反应控制以及再生过程中的轴突生长。我们已经研究了角膜神经支配的三叉神经节神经元和上皮神经末梢或父母轴突的急性损伤后正常末梢重塑期间c-Jun的表达。重塑和重排，或仅限于角膜上皮末端的损害，不是激活c-Jun表达的触发因素。然而，基质或眶睫状神经中亲本轴突的损伤诱导了50％的角膜神经元人口中的c-Jun表达，其中包括所有大的髓鞘和20％的小神经肽含角膜神经元。这表明三叉神经节神经元中的c-Jun表达与周围神经末梢的正常重塑或再生无关，并且仅在父轴突受伤时才会发生。大量受损的神经元不表达c-Jun，这表明在原代感觉神经元中，损伤和再生可能并不总是与该原癌基因的表达相关。

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