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首页> 外文期刊>The European Journal of Neuroscience >Long-trace interval eyeblink conditioning is impaired in mutant mice lacking the NMDA receptor subunit epsilon 1.
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Long-trace interval eyeblink conditioning is impaired in mutant mice lacking the NMDA receptor subunit epsilon 1.

机译：在缺少NMDA受体亚基epsilon 1的突变小鼠中，长距离间隔眨眼条件受损。

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摘要

To elucidate the role of the N-methyl-D-aspartate (NMDA) -type glutamate receptor subunit epsilon 1 (GluR epsilon 1) in classical eyeblink conditioning, delay and trace eyeblink conditioning were investigated in GluR epsilon 1-null mutant mice. In delay conditioning and short-trace interval conditioning with a trace interval of 250 ms, GluR epsilon 1 mutant mice attained a normal level of the conditioned response (CR), although acquisition was a little slower than in wild-type mice. In contrast, GluR epsilon 1 mutant mice exhibited severe impairment of the attained level of the CR and disturbed temporal pattern of CR expression in trace conditioning with a longer trace interval of 500 ms. These findings indicate that GluR epsilon 1 is essential for long-trace interval eyeblink conditioning. The impairments of the associative learning with a long temporal separation between the conditioned and unconditioned stimuli observed in the GluR epsilon 1 mutant mice could be attributed to an impairment of hippocampal long-term potentiation in this line of mutant mice.
机译：为了阐明N-甲基-D-天冬氨酸（NMDA）型谷氨酸受体亚基ε1（GluR epsilon 1）在经典眨眼条件中的作用，在GluR epsilon 1-null突变小鼠中研究了延迟和痕量眨眼条件。在延迟条件和跟踪间隔为250毫秒的短跟踪间隔条件下，GluR epsilon 1突变小鼠达到了正常水平的条件响应（CR），尽管获取速度比野生型小鼠慢一点。相比之下，GluR epsilon 1突变小鼠表现出严重的CR达到水平的损害，并在具有500 ms的较长跟踪间隔的跟踪条件下扰乱了CR表达的时间模式。这些发现表明，GluR epsilon 1对于长时间跟踪眨眼条件至关重要。在GluR epsilon 1突变小鼠中观察到的条件和非条件刺激之间存在较长时间间隔的联想学习障碍可能归因于该突变小鼠系中的海马长期增强作用。

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