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首页> 外文期刊>The European Journal of Neuroscience >Specific role of the posterior dorsal hippocampus-prefrontal cortex in short-term working memory.
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Specific role of the posterior dorsal hippocampus-prefrontal cortex in short-term working memory.

机译：后背海马-前额叶皮层在短期工作记忆中的特定作用。

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摘要

Working memory in rats involves neural projections from the hippocampus (HP) to the prefrontal cortex (PFC), based on delayed task experiments in a radial-arm maze, in which the time span of working memory is longer than seconds. To determine whether the HP-PFC pathway is involved in short-term (on the order of seconds) working memory function, we lesioned the PFC and/or HP, and measured performance in an operant delayed alternation task. The posterior dorsal (pdHP) and ventral HP (vHP) were assessed separately. The bilateral PFC and bilateral pdHP ibotenate lesions produced significant working memory deficits, but the vHP lesion did not. Unilateral pdHP lesions combined with a PFC lesion in the opposite hemisphere reproduced the effects of bilaterally symmetrical lesions. By contrast, unilateral lesions of the pdHP combined with a PFC lesion in the same hemisphere had no effect on delayed alternation. These results indicate that the pdHP-PFC pathway is essential for working memory on the order of seconds in rats, and suggest that the pdHP and vHP pathways to the PFC play different behavioral roles.
机译：大鼠的工作记忆涉及从海马（HP）到前额叶皮层（PFC）的神经投射，这是基于在arm臂迷宫中进行的延迟任务实验而得出的，其中工作记忆的时间跨度比秒长。为了确定HP-PFC通路是否参与短期（以秒为单位）的工作记忆功能，我们损伤了PFC和/或HP，并测量了操作性延迟交替任务中的性能。分别评估后背（pdHP）和腹侧HP（vHP）。双侧PFC和双侧pdHP ibotenate病变产生明显的工作记忆缺陷，但vHP病变则没有。单侧pdHP病变与对侧半球的PFC病变相结合，再现了双侧对称病变的影响。相比之下，在同一半球中，pdHP的单侧病变与PFC病变相结合对延迟交替没有影响。这些结果表明，pdHP-PFC途径对于大鼠数秒内的工作记忆必不可少，并且表明通往PFC的pdHP和vHP途径起着不同的行为作用。

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