...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The European Journal of Neuroscience >Specific inhibitory synapses shift the balance from feedforward to feedback inhibition of hippocampal CA1 pyramidal cells.
【24h】

Specific inhibitory synapses shift the balance from feedforward to feedback inhibition of hippocampal CA1 pyramidal cells.

机译：特定的抑制性突触将平衡从前馈转变为对海马CA1锥体细胞的反馈抑制。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Feedforward and feedback inhibition are two fundamental modes of operation widespread in the nervous system. We have functionally identified synaptic connections between rat CA1 hippocampal interneurons of the stratum oriens (SO) and interneurons of the stratum lacunosum moleculare (SLM), which can act as feedback and feedforward interneurons, respectively. The unitary inhibitory postsynaptic currents (uIPSCs) detected with K-gluconate-based patch solution at -50 mV had an amplitude of 20.0 +/- 2.0 pA, rise time 2.2 +/- 0.2 ms, decay time 25 +/- 2.2 ms, jitter 1.4 +/- 0.2 ms (average +/- SEM, n = 39), and were abolished by the gamma-aminobutyric acid (GABA)(A) receptor antagonist 2-(3-carboxypropyl)-3-amino-6-methoxyphenyl-pyridazinium bromide (SR 95531). Post hoc anatomical characterization revealed that all but one of the identified presynaptic neurons were oriens-lacunosum moleculare (O-LM) cells, whereas the postsynaptic neurons were highly heterogeneous, including neurogliaform (n = 4), basket (n = 4), Schaffer collateral-associated (n = 10) and perforant path-associated (n = 9) cells. We investigated the short-term plasticity expressed at these synapses, and found that stimulation at 10-40 Hz resulted in short-term depression of uIPSCs. This short-term plasticity was determined by presynaptic factors and was not target-cell specific. We found that the feedforward inhibition elicited by the direct cortical input including the perforant path onto CA1 pyramidal cells was modulated through the inhibitory synapses we have characterized. Our data show that the inhibitory synapses between interneurons of the SO and SLM shift the balance between feedback and feedforward inhibition onto CA1 pyramidal neurons.
机译：前馈和反馈抑制是神经系统中广泛使用的两种基本操作模式。我们已经在功能上确定了大鼠CA1海马层间神经元（SO）和腔隙层分子（SLM）的神经元之间的突触连接，它们可以分别充当反馈和前馈性神经元。用基于葡萄糖酸钾的贴片溶液在-50 mV处检测到的单位抑制性突触后电流（uIPSC）的幅度为20.0 +/- 2.0 pA，上升时间为2.2 +/- 0.2 ms，衰减时间为25 +/- 2.2 ms，抖动1.4 +/- 0.2毫秒（平均+/- SEM，n = 39），并被γ-氨基丁酸（GABA）（A）受体拮抗剂2-（3-羧丙基）-3-氨基-6-消除了甲氧基苯基吡啶鎓溴化物（SR 95531）。事后的解剖学特征表明，除了一个已识别的突触前神经元以外，其他所有细胞都是oriens-lacunosum分子（O-LM）细胞，而突触后神经元的异质性很高，包括神经胶质细胞（n = 4），篮子（n = 4），Schaffer侧支相关细胞（n = 10）和穿孔路径相关细胞（n = 9）。我们调查了在这些突触中表达的短期可塑性，发现在10-40 Hz的刺激会导致uIPSC的短期抑制。这种短期可塑性是由突触前因素决定的，而不是靶细胞特异性的。我们发现，通过直接皮质输入（包括通往CA1锥体细胞的穿孔路径）引起的前馈抑制是通过我们表征的抑制性突触进行调节的。我们的数据表明，SO和SLM中间神经元之间的抑制性突触将反馈和前馈抑制之间的平衡转移到了CA1锥体神经元上。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号