...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The European Journal of Neuroscience >Pathway-dependent modulation by P2-purinoceptors in the mouse retina.
【24h】

Pathway-dependent modulation by P2-purinoceptors in the mouse retina.

机译：P2-嘌呤受体在小鼠视网膜中的途径依赖性调节。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Adenosine trisphosphate (ATP) activates purinoceptors and acts as a neurotransmitter in the nervous system. In the retina, we previously reported that the immunohistochemical distribution of the subset of P2-purinoceptors differs between the ON and OFF pathways. Here, we investigated whether ATP activates P2-purinoceptors and modulates the physiological function of the mouse retina. We also examined if signal processing by P2-purinoceptors is pathway specific. Results showed that ATP activated both ON- and OFF-cholinergic amacrine cells. However, responses in OFF-cholinergic amacrine cells were greater than those in ON-cholinergic amacrine cells. Pharmacological studies in OFF-cholinergic amacrine cells showed that the response of OFF-cholinergic amacrine cells is mediated P2X(2)-purinoceptors. Further, ATP increased gamma-aminobutyric acid (GABA)ergic inhibitory postsynaptic currents (IPSCs) in OFF- but not ON-cholinergic amacrine cells. The increase in GABAergic IPSCs was mediated by P2-purinoceptors. P2-purinoceptor-mediated signals suppressed OFF ganglion cells but activated ON ganglion cells. Our findings indicate that ATP physiologically modulates signal processing of the ON and OFF pathways in a pathway-specific manner through P2-purinoceptors.
机译：三磷酸腺苷（ATP）激活嘌呤受体并在神经系统中充当神经递质。在视网膜中，我们先前曾报道过P2-嘌呤受体的亚组的免疫组织化学分布在ON和OFF通路之间有所不同。在这里，我们调查了ATP是否激活P2-嘌呤受体并调节小鼠视网膜的生理功能。我们还检查了P2-嘌呤受体的信号处理是否是通路特异性的。结果显示，ATP激活了ON和OFF胆碱能无长突细胞。但是，OFF-胆碱能的无长突细胞中的反应大于ON-胆碱能的无长突细胞中的反应。 OFF胆碱能的无长突细胞的药理研究表明OFF胆碱能的无长突细胞的反应是介导的P2X（2）-嘌呤受体。此外，ATP增加了OFF胆碱能无蛋白细胞中的γ-氨基丁酸（GABA）能量抑制性突触后电流（IPSC）。 GABA能的IPSC的增加是由P2-嘌呤受体介导的。 P2-嘌呤受体介导的信号抑制神经节细胞关闭，但激活神经节细胞激活。我们的发现表明，ATP通过P2-嘌呤受体以特定于途径的方式生理性地调节ON和OFF途径的信号处理。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号