...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The European Journal of Neuroscience >Pavlovian fear conditioning as a behavioral assay for hippocampus and amygdala function: cautions and caveats.
【24h】

Pavlovian fear conditioning as a behavioral assay for hippocampus and amygdala function: cautions and caveats.

机译：巴甫洛夫式恐惧调节作为海马和杏仁核功能的行为分析：警告和警告。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Pavlovian fear conditioning has become an important model for investigating the neural substrates of learning and memory in rats, mice and humans. The hippocampus and amygdala are widely believed to be essential for fear conditioning to contexts and discrete cues, respectively. Indeed, this parsing of function within the fear circuit has been used to leverage fear conditioning as a behavioral assay of hippocampal and amygdala function, particularly in transgenic mouse models. Recent work, however, blurs the anatomical segregation of cue and context conditioning and challenges the necessity for the hippocampus and amygdala in fear learning. Moreover, nonassociative factors may influence the performance of fear responses under a variety of conditions. Caution must therefore be exercised when using fear conditioning as a behavioral assay for hippocampal- and amygdala-dependent learning.
机译：巴甫洛夫式恐惧调节已成为研究大鼠，小鼠和人类学习和记忆的神经基础的重要模型。人们普遍认为，海马和杏仁核分别对适应环境和离散线索的恐惧至关重要。实际上，恐惧回路内的这种功能解析已被用来利用恐惧条件作为海马和杏仁核功能的行为分析，特别是在转基因小鼠模型中。然而，最近的工作模糊了提示和情境条件的解剖隔离，并在恐惧学习中挑战了海马和杏仁核的必要性。此外，非关联因素可能会影响各种条件下恐惧反应的表现。因此，在使用恐惧条件作为海马依赖和杏仁核依赖学习的行为分析时，必须谨慎行事。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号