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首页> 外文期刊>The European Journal of Neuroscience >DeltaFosB accumulation in ventro-medial caudate underlies the induction but not the expression of behavioral sensitization by both repeated amphetamine and stress.
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DeltaFosB accumulation in ventro-medial caudate underlies the induction but not the expression of behavioral sensitization by both repeated amphetamine and stress.

机译：DeltaFosB在尾内侧内侧的积累是诱导的基础，而不是由反复的苯丙胺和应激引起的行为敏化的表达的基础。

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摘要

Both repeated psychostimulants and stress have the ability to promote behavioral sensitization, i.e. enhanced behavioral response to drug challenge. To test whether the behavioral phenotype is also accompanied by similar neuroplastic adaptations, the present study evaluated changes in Fos and FosB/DeltaFosB transcription factors induced in the brain of C57BL/6J mice behaviorally sensitized by repeated amphetamine or repeated restraint stress. Groups of mice received repeated injections of D-amphetamine or saline in group-specific environments. Different groups of mice experienced 2 h of restraint daily for 10 consecutive days. Amphetamine- pre-treated mice, drug-challenged in the environment in which they received drug treatments (Paired), as well as repeatedly stressed mice expressed robust sensitization to the locomotor effects of amphetamine. Both stress- and amphetamine-pre-treated groups showed changes in amphetamine-induced Fos expression; however, none of these changes was shared by the two sensitizing treatments. Instead, accumulation of FosB/DeltaFosB immunoreactivity in the ventro-medial caudate was common to both pre-treatments. These results support the hypothesis that a common neuroadaptive process involving DeltaFosB accumulation in the ventro-medial caudate underlies the induction but not the expression of behavioral sensitization by different conditions.
机译：反复的精神兴奋剂和压力都具有促进行为敏化的能力，即增强了对药物激发的行为反应。为了测试行为表型是否还伴有类似的神经增生适应性，本研究评估了通过反复苯丙胺或反复束缚应激对行为敏感的C57BL / 6J小鼠的大脑中诱导的Fos和FosB / DeltaFosB转录因子的变化。在特定组的环境中，每组小鼠重复注射D-苯异丙胺或盐水。不同组的小鼠每天连续2天每天有2小时的约束。苯丙胺预处理的小鼠在接受药物治疗的环境中受到药物攻击（配对），并且反复受压的小鼠对苯丙胺的运动作用表现出强烈的敏感性。应激和苯丙胺预处理组均显示苯丙胺诱导的Fos表达发生变化;但是，这两种敏化治疗方法均没有这些变化。取而代之的是，FosB / DeltaFosB免疫反应性在尾状腹内侧中的积累对于两种预处理都是常见的。这些结果支持一个假设，即涉及DeltaFosB累积在腹内侧尾状肌中的常见神经适应过程是诱导的基础，而不是不同条件下行为敏化的表达。

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