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首页> 外文期刊>The European Journal of Neuroscience >Phase-coupled oscillator models can predict hippocampal inhibitory synaptic connections.
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Phase-coupled oscillator models can predict hippocampal inhibitory synaptic connections.

机译：相位耦合振荡器模型可以预测海马抑制性突触连接。

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摘要

What factors are responsible for propagating electrical activity in the hippocampus? Using an intact, isolated hippocampus preparation, it is possible to observe spontaneous delta (< or = 4 Hz) waves of rhythmic field potentials. These rhythmic potentials are inhibitory in nature, mediated by GABAergic inhibitory potentials originating from a population of principal neurons. They start in the ventro-temporal region and move longitudinally towards the dorso-septal region with a phase lag of approximately 10% between the extracellular recordings. We use the mathematical framework of phase-coupled oscillators (PCO) to gain some insight into the underlying network system. A chain of 15 nearest-neighbour bidirectionally coupled PCOs is used where each oscillator refers to a segment of the CA1 region of the hippocampus that can generate these slow field potentials. We find that ventro-dorsal delta waves exist if there is a dominance in coupling strength in one direction. Without a one-way coupling dominance, ventro-dorsal waves can still exist, but then the coupling strengths need to be much larger. The relationship between entrained and intrinsic frequencies and the variation of propagation speeds along the longitudinal axis can be used to determine which case applies. Currently available experimental data supports one of the cases, predicting that there is a stronger ventral to dorsal inhibitory effect.
机译：哪些因素在海马中传播电活动？使用完整的，分离的海马制剂，可以观察到有节奏的场电位的自发三角波（<或= 4 Hz）。这些节律性电位在本质上是抑制性的，由源自主要神经元群体的GABA能性抑制性电位介导。它们始于腹颞区，并朝背中隔区纵向移动，在细胞外记录之间的相位滞后约为10％。我们使用相位耦合振荡器（PCO）的数学框架来深入了解底层网络系统。使用15个最近邻双向耦合PCO的链，其中每个振荡器都指向海马CA1区域的一部分，该片段可以产生这些慢磁场电势。我们发现，如果在一个方向上的耦合强度占优势，则存在腹背三角波。没有单向耦合优势，腹背波仍然会存在，但是耦合强度需要更大。夹带频率和固有频率之间的关系以及沿纵轴的传播速度变化可用于确定哪种情况适用。当前可获得的实验数据支持了其中一种情况，预言了腹侧对背侧的抑制作用更强。

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