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首页> 外文期刊>The European Journal of Neuroscience >The isochronic band hypothesis and climbing fibre regulation of motricity: an experimental study.
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The isochronic band hypothesis and climbing fibre regulation of motricity: an experimental study.

机译：等时带假说和爬电纤维调节度：一项实验研究。

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The dynamic organization of the olivocerebellar afferent input to Purkinje cells was examined in rat cerebellar cortex. The distribution of synchronous Purkinje cell complex spike activity was characterized, bilaterally, utilizing multiple electrode recordings in crus IIa folium under ketamine anaesthesia. The results confirmed the existence of rostrocaudal complex spike isochronicity bands with a mediolateral width of 500 microm. For a given band, no finer spatial submicrostructures could be discerned at a first-order approximation (two-dimensional projection). Closer analysis determined that isochronicity between bands is not continuous in space but demonstrates discrete discontinuities at the mediolateral boundaries. Principal component multivariate analysis revealed that the first principal component of the spatio-temporal variance is synchronicity along the rostrocaudal band with a decreased level of coupling in the mediolateral direction at the band boundary. Furthermore, this discrete banding isochronicity is organized by the distribution of feedback inhibition from the cerebellar nuclei on to the inferior olive nucleus. The usual multiple band structure can be dynamically altered to a single wide-band dynamic architecture, or to other patterns of activity, as may be required by movement coordination.
机译：在大鼠小脑皮质中检查了浦肯野细胞的小脑传入神经输入的动态组织。在氯胺酮麻醉下，利用多电极记录在结节IIa大叶中双向表征同步的Purkinje细胞复合物刺突活性的分布。结果证实存在具有500微米的中外侧宽度的罗尾尾复合尖峰等时性带。对于给定的波段，一阶近似（二维投影）无法分辨出更精细的空间亚显微结构。进一步的分析确定，频带之间的等时性在空间上不是连续的，而是表明在中外侧边界处存在离散的不连续性。主成分多变量分析显示，时空方差的第一个主成分是沿后尾带的同步性，在带边界的中外侧方向上的耦合程度降低。此外，这种离散的带状等时性是通过从小脑核到下橄榄核的反馈抑制分布来组织的。可以将通常的多频段结构动态更改为单个宽带动态体系结构，或者更改为其他运动模式，这可能是运动协调所要求的。

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