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首页> 外文期刊>The European Journal of Neuroscience >Modulation of the amplitude of gamma-band activity by stimulus phase enhances signal encoding.
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Modulation of the amplitude of gamma-band activity by stimulus phase enhances signal encoding.

机译：刺激相位对伽马波段活动幅度的调制可增强信号编码。

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摘要

Visual stimulation often leads to elevated fluctuations of the membrane potential in the gamma-frequency range (25-70 Hz) in visual cortex neurons. Recently, we have found that the strength of gamma-band fluctuations is coupled to the oscillation of the membrane potential at the temporal frequency of the stimulus, so that the gamma-band fluctuations are stronger at depolarization peaks, but weaker at troughs of the stimulus frequency oscillation of the membrane potential. We hypothesized that this coupling may improve stimulus encoding. Here, we tested this hypothesis by using a single-compartment conductance-based neuron model, with parameters of the input adjusted to reproduce typical features of membrane potential and spike responses, recorded in cat visual cortical neurons in vivo during the presentation of moving gratings. We show that modulation of the gamma-range membrane potential fluctuations by the amplitude of the slow membrane depolarization greatly improves stimulus encoding. Moreover, changing the degree of modulation of the gamma-activity by the low-frequency signal within the range typically observed in visual cortex cells had a stronger effect on both the firing rates and information rates than changing the amplitude of the low-frequency stimulus itself. Thus, modulation of the gamma-activity represents an efficient mechanism for regulation of neuronal firing and encoding of the temporal characteristics of visual stimuli.
机译：视觉刺激通常会导致视觉皮层神经元在伽马频率范围（25-70 Hz）中膜电位的升高波动。最近，我们发现伽马能带波动的强度与刺激时间频率上膜电位的振荡有关，因此，伽马能带波动在去极化峰处较强，而在刺激波谷处较弱。膜电位的频率振荡。我们假设这种耦合可以改善刺激编码。在这里，我们通过使用基于单室电导的神经元模型测试了这一假设，并调整了输入参数以重现膜电位和尖峰响应的典型特征，并在运动光栅呈现过程中将其记录在体内的猫视觉皮层神经元中。我们表明，通过慢速膜去极化的幅度来调节伽玛范围的膜电势波动极大地改善了刺激编码。此外，在视觉皮层细胞中通常观察到的范围内，通过低频信号改变伽马活性的调制度，对发声率和信息率的影响均大于改变低频刺激本身的幅度。 。因此，伽马活性的调节代表了调节神经元放电和视觉刺激的时间特性的编码的有效机制。

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