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首页> 外文期刊>The European Journal of Neuroscience >Site-dependent and state-dependent inhibition of pruritogen-responsive spinal neurons by scratching
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Site-dependent and state-dependent inhibition of pruritogen-responsive spinal neurons by scratching

机译：通过刮擦对位点和状态依赖的对促甜素反应性脊神经元的抑制

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The relief of itch by scratching is thought to involve inhibition of pruritogen-responsive neurons in the spinal cord. We recorded the responses of superficial dorsal horn neurons in mice to intradermal injection of the pruritogens chloroquine and histamine. Scratching within an area 5-17mm distant from the injection site, outside of the units' mechanoreceptive fields (off-site), significantly inhibited chloroquine-evoked and histamine-evoked responses without affecting capsaicin-evoked firing. This is consistent with observations that scratching at a distance from a site of itch is antipruritic. In contrast, scratching directly at the injection site (within the receptive field; on-site) had no effect on chloroquine-evoked neuronal firing, but enhanced the same neurons' responses to intradermal injection of the algogen capsaicin. Moreover, neuronal responses to histamine were enhanced during on-site scratching, and this was followed by suppression of firing below baseline levels after termination of scratching. Scratching thus inhibits pruritogen-responsive neurons in a manner that depends on the input modality (i.e. pain vs. histamine-dependent or histamine-independent itch) and skin location. We investigated if scratching inhibits pruritogen-responsive superficial dorsal horn neurons to relieve itch. Scratching outside the mechanosensitive receptive field inhibited chloroquine- and histamine- but not capsaicin-evoked responses. Scratching within the receptive field enhanced neuronal firing evoked by histamine and capsaicin. Histamine-evoked firing was attenuated post-scratching. Scratching thus inhibits pruritogen-responsive neurons in a site- and modality-dependent manner.
机译：据认为，通过抓挠减轻瘙痒涉及抑制脊髓中对促红素反应性神经元。我们记录了小鼠浅表背角神经元对皮内注射致敏原氯喹和组胺的反应。在远离注射部位5-17mm的区域内（在装置的机械感受力场外）刮擦（异位）可显着抑制氯喹诱发和组胺诱发的反应，而不会影响辣椒素诱发的放电。这与在瘙痒部位远处抓挠止痒的观察结果一致。相反，直接在注射部位（在感受野内;在现场）抓挠对氯喹诱发的神经元放电没有影响，但会增强相同神经元对皮内注射致癌物辣椒素的反应。此外，在现场抓挠过程中，对组胺的神经元反应增强了，随后在抓挠终止后将放电抑制在基线水平以下。因此，抓痒以取决于输入方式（即疼痛与组胺依赖性或组胺依赖性或不依赖组胺的瘙痒）和皮肤位置的方式抑制对促红素反应性神经元。我们研究了抓挠是否抑制了果糖原反应性浅表背角神经元以减轻瘙痒。在机械敏感性感受野外刮擦会抑制氯喹和组胺反应，但不会抑制辣椒素引起的反应。在感受野内抓挠会增强组胺和辣椒素引起的神经元放电。组胺诱发的烧伤在刮擦后减弱。因此，抓痒以部位和形态依赖的方式抑制了对促红素反应性神经元。

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