...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The European Journal of Neuroscience >Formerly known as inhibitory: Effects of 1-Hz rTMS on auditory cortex are state-dependent
【24h】

Formerly known as inhibitory: Effects of 1-Hz rTMS on auditory cortex are state-dependent

机译：前称抑制性：1-Hz rTMS对听觉皮层的影响取决于状态

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The major repetitive transcranial magnetic stimulation (rTMS) paradigm applied to the treatment of tinnitus has been the 1-Hz variant due to its alleged inhibitory effects. Clinical effects have, however, been hampered by great interindividual variability as well as the fact that TMS includes no explicit mechanism to modulate excitability in circumscribed regions of tonotopically organised auditory fields. Following studies showing that the effect of TMS depends on the activational state preceding the stimulation, participants were exposed to 10min of either notch- or bandpass-filtered noise prior to 1-Hz rTMS applied to the left auditory cortex. A control group was additionally assessed using bandpass noise - albeit with subsequent sham stimulation - to assess whether effects were due to the differential sounds alone or to a genuine interaction between sound and rTMS. Electroencephalogram was recorded from 128 electrodes before and after the experimental treatment while participants performed an auditory intensity discrimination task. While state-dependency effects from the behavioural data are not conclusive, several condition×(sound) frequency effects (some specific to the stimulated side) could be observed. Importantly, many of these could not be explained by the use of rTMS or the filtered noise alone. The resulting patterns are, however, complex and temporally variable, which currently prohibits recommendations on how to design a clinically effective approach to treat tinnitus. Nevertheless, our study gives the first evidence that state-dependency principles can induce sound frequency-specific effects in the auditory cortex, providing a crucial proof-of-principle upon which future studies can build.
机译：用于耳鸣治疗的主要重复经颅磁刺激（rTMS）范例由于其所谓的抑制作用而成为1-Hz变异。然而，巨大的个体间差异以及TMS不包含任何明显的机制来调节局部性听觉区域的边界区域内的兴奋性，阻碍了临床效果。继研究表明TMS的效果取决于刺激之前的激活状态后，在将1-Hz rTMS应用于左听觉皮层之前，参与者会经历10分钟的陷波或带通滤波噪声。对照组还使用带通噪声（尽管随后进行了假刺激）进行评估，以评估其影响是仅由于声音的差异还是由于声音与rTMS之间真正的相互作用所致。在参与者进行听觉强度辨别任务的同时，从实验治疗前后的128个电极记录脑电图。尽管来自行为数据的状态相关性效应不是结论性的，但可以观察到几种条件×（声音）频率效应（某些特定于受激侧）。重要的是，许多这些无法仅通过使用rTMS或单独的滤波噪声来解释。然而，所产生的模式是复杂的且在时间上可变的，当前禁止有关如何设计临床有效的耳鸣治疗方法的建议。然而，我们的研究提供了第一个证据，即状态依赖性原理可以在听觉皮层中诱导特定的声音频率效应，为以后的研究提供了至关重要的原理证明。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号