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首页> 外文期刊>The European Journal of Neuroscience >Anxiolytic- and panicolytic-like effects of Neuropeptide S in the mouse elevated T-maze
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Anxiolytic- and panicolytic-like effects of Neuropeptide S in the mouse elevated T-maze

机译：神经肽S在小鼠升高的T迷宫中的抗焦虑和胰腺溶解样作用

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摘要

Neuropeptide S (NPS) regulates various biological functions by selectively activating the NPS receptor (NPSR). Recently, epidemiological studies revealed an association between NPSR single nucleotide polymorphisms and susceptibility to panic disorders. Here we investigated the effects of NPS in mice subjected to the elevated T maze (ETM), an assay which has been proposed to model anxiety and panic. Diazepam [1mg/kg, intraperitoneally (i.p.)] elicited clear anxiolytic effects reducing the latency to emerge from the closed to the open (CO) arm without modifying the latencies from the open to the closed (OC) arm. By contrast, chronic fluoxetine (10mg/kg i.p., once a day for 21days) selectively increased OC latency, suggesting a panicolytic-like effect. NPS given intracerebroventricularly at 0.001-1nmol elicited both anxiolytic- and panicolytic-like effects. However, although the NPS anxiolytic dose-response curve displayed the classical sigmoidal shape, the dose-response curve of the putative panicolytic-like effect was bell shaped with peak effect at 0.01nmol. The behaviour of wild-type [NPSR(+/+)] and receptor knock out [NPSR(-/-)] mice in the ETM task was superimposable. NPS at 0.01nmol elicited anxiolytic- and panicolytic-like effects in NPSR(+/+) but not in NPSR(-/-) mice. In conclusion, this study demonstrated that NPS, via selective activation of the NPSR, promotes both anxiolytic- and panicolytic-like actions in the mouse ETM. Neuropeptide S (NPS) promotes anxiolytic- and panicolytic-like effects in the mouse elevated T maze via selective activation of the NPS receptor.
机译：神经肽S（NPS）通过选择性激活NPS受体（NPSR）来调节各种生物学功能。最近，流行病学研究揭示了NPSR单核苷酸多态性与惊慌症易感性之间的关联。在这里，我们研究了NPS对高架T迷宫（ETM）小鼠的影响，该方法已被提出用于模拟焦虑和惊恐模型。地西p [1mg / kg，腹膜内（i.p.）]引起明显的抗焦虑作用，减少了从闭合到开放（CO）臂出现的潜伏期，而没有改变从开放到闭合（OC）臂的潜伏期。相比之下，慢性氟西汀（10mg / kg i.p.，每天一次，持续21天）有选择地增加OC潜伏期，表明有类似panicolytic的作用。脑室内以0.001-1nmol的剂量给予NPS会引起抗焦虑和panicolytic类效应。然而，尽管NPS抗焦虑剂量反应曲线显示出经典的S形，但假定的类药分解作用的剂量反应曲线是钟形的，在0.01nmol处具有峰值作用。 ETM任务中的野生型[NPSR（+ / +）]和敲除受体[NPSR（-/-）]小鼠的行为是可叠加的。 NPS在0.01nmol时在NPSR（+ / +）中引起抗焦虑和Panicolytic样效应，但在NPSR（-/-）小鼠中则没有。总而言之，这项研究表明NPS通过选择性激活NPSR来促进小鼠ETM中的抗焦虑药和类似panicolytic的作用。神经肽S（NPS）通过选择性激活NPS受体，在小鼠升高的T迷宫中促进抗焦虑和胰腺溶解样作用。

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