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首页> 外文期刊>The European Journal of Neuroscience >Subthalamic nucleus stimulation restores the efferent cortical drive to muscle in parallel to functional motor improvement
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Subthalamic nucleus stimulation restores the efferent cortical drive to muscle in parallel to functional motor improvement

机译：丘脑底核刺激可恢复皮质传出的肌肉驱动力，同时改善运动功能

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摘要

Pathological synchronization in large-scale motor networks constitutes a pathophysiological hallmark of Parkinson's disease (PD). Corticomuscular synchronization in PD is pronounced in lower frequency bands (<10Hz), whereas efficient cortical motor integration in healthy persons is driven in the beta frequency range. Electroencephalogram and electromyogram recordings at rest and during an isometric precision grip task were performed in four perioperative sessions in 10 patients with PD undergoing subthalamic nucleus deep-brain stimulation: (i) 1day before (D0); (ii) 1day after (D1); (iii) 8days after implantation of macroelectrodes with stimulation off (D8StimOff); and (iv) on (D8StimOn). Analyses of coherence and phase delays were performed in order to challenge the effects of microlesion and stimulation on corticomuscular coherence (CMC). Additionally, local field potentials recorded from the subthalamic nucleus on D1 allowed comprehensive mapping of motor-related synchronization in subthalamocortical and cerebromuscular networks. Motor performance improved at D8StimOn compared with D0 and D8StimOff paralleled by a reduction of muscular activity and CMC in the theta band (3.9-7.8Hz) and by an increase of CMC in the low-beta band (13.7-19.5Hz). Efferent motor cortical drives to muscle presented mainly below 10Hz on D8StimOff that were suppressed on D8StimOn and occurred on higher frequencies from 13 to 45Hz. On D1, coherence of the high-beta band (20.5-30.2Hz) increased during movement compared with rest in subthalamomuscular and corticomuscular projections, whereas it was attenuated in subcorticocortical projections. The present findings lend further support to the concept of pathological network synchronization in PD that is beneficially modulated by stimulation.
机译：大规模运动网络中的病理同步是帕金森氏病（PD）的病理生理学标志。在较低的频段（<10Hz）中，PD的皮质神经同步明显，而健康人的有效皮质运动在β频率范围内有效。在10例接受丘脑底核深脑刺激的PD患者的围手术期的四个围手术期中，进行了静态和等距精确抓地任务期间的脑电图和肌电图记录：（i）前一天（D0）; （ii）（D1）后1天; （iii）植入大电极后关闭刺激8天（D8StimOff）; （iv）在（D8StimOn）上。进行相干和相位延迟分析，以挑战微损伤和刺激对皮层细胞相干性（CMC）的影响。此外，从丘脑底核在D1上记录的局部电场电势可以全面映射丘脑皮质和脑肌肉网络中与运动有关的同步。与D0和D8StimOff相比，D8StimOn的运动性能得到改善，同时theta频段（3.9-7.8Hz）的肌肉活动和CMC减少，以及低beta频段（13.7-19.5Hz）的CMC增加。传出的运动皮质对肌肉的驱动主要在D8StimOff上的10Hz以下出现，而在D8StimOn上受到抑制，并在13到45Hz的较高频率下出现。在D1上，丘脑膜下和皮质小球投影中的高β波段（20.5-30.2Hz）的相干性在运动过程中比静止时增加，而在皮层下皮质投影中则减弱。本发现进一步支持PD中病理网络同步的概念，其通过刺激有益地调节。

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